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Reserpine alleviates cisplatin-induced acute kidney injury via anti-ferroptosis and cGAS/STING pathway.
Ren Fail
December 2024
Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Cisplatin plays a pivotal role in the chemotherapy treatment of various cancers, but its use is often limited due to its nephrotoxic side effects. Identifying compounds that can mitigate cisplatin-induced nephrotoxicity is therefore of great importance. This study focused on evaluating the protective effects of reserpine against cisplatin-induced acute kidney injury.
View Article and Find Full Text PDFImpact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses.
Neurotox Res
October 2024
Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
The 5-lipoxygenase/leukotriene system has been implicated in both physiological and pathological states within the central nervous system. Understanding how this system interacts with the dopaminergic system could provide valuable insights into dopamine-related pathologies. This study focused on examining both motor and non-motor dopamine-related responses in 5-lipoxygenase/leukotriene-deficient mice.
View Article and Find Full Text PDFPharmacological Evidence of Eugenia Brasiliensis Leaves in a Reserpine-Induced Fibromyalgia Model: Antinociceptive, Emotional, Anti-Inflammatory, and Neurotrophic Effects.
Mol Neurobiol
November 2024
Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Center for Biological Sciences, Federal University of Santa Catarina, Trindade, Florian?polis, SC, 88040-900, Brazil.
Fibromyalgia (FM) is a painful chronic condition that significantly impacts the quality of life, posing challenges for clinical management. Given the difficulty of understanding the pathophysiology and finding new therapeutics, this study explored the effects of a medicinal plant, E. brasiliensis, in an FM model induced by reserpine in Swiss mice.
View Article and Find Full Text PDFAC-73 and Syrosingopine Inhibit SARS-CoV-2 Entry into Megakaryocytes by Targeting CD147 and MCT4.
Viruses
January 2024
National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy.
Coagulation disorders are described in COVID-19 and long COVID patients. In particular, SARS-CoV-2 infection in megakaryocytes, which are precursors of platelets involved in thrombotic events in COVID-19, long COVID and, in rare cases, in vaccinated individuals, requires further investigation, particularly with the emergence of new SARS-CoV-2 variants. CD147, involved in the regulation of inflammation and required to fight virus infection, can facilitate SARS-CoV-2 entry into megakaryocytes.
View Article and Find Full Text PDFRisk Assessment of Psychotropic Drugs on Mitochondrial Function Using In Vitro Assays.
Biomedicines
December 2023
Department of Pharmaceutical Sciences, Barry & Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Ft. Lauderdale, FL 33328-2018, USA.
Article Synopsis
- This study explores how 22 psychotropic drugs affect mitochondrial function, specifically looking at their potential to cause organ toxicity.
- Several drugs were found to inhibit the electron transport chain (ETC) or act as uncouplers, with varying levels of cytotoxicity identified in HepG2 cells and isolated rat liver mitochondria.
- The findings help clarify the molecular mechanisms behind drug-induced mitochondrial toxicity, which can inform safer clinical drug choices.
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