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High-affinity uric acid clearance based on motile β-CD/F-127 polyrotaxane microspheres for enhanced diabetic wound repair.
Carbohydr Polym
March 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Institute of Biomedical Engineering, Jinan University, Guangzhou 510632, China. Electronic address:
Hyperuricemia-related diabetic wounds are notoriously difficult to treat due to elevated uric acid (UA) levels, excessive reactive oxygen species (ROS), and chronic inflammation. Current therapies often fail to address these underlying causes, underscoring the need for innovative approaches that not only clear UA but also mitigate inflammation and promote tissue regeneration. In this study, we developed a polyrotaxane-based microsphere (HPR MS) system conjugated with 4,5-diamino-2-thiouracil (DT) to achieve high-affinity UA clearance without increasing cytotoxicity.
View Article and Find Full Text PDFInvestigation of Gallium(III) Complexes with Thiouracil Derivatives: Effects of pH on Coordination and Stability.
Int J Mol Sci
November 2024
Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland.
Article Synopsis
- The study investigates new complexes formed between gallium(III) and various thiouracil derivatives, examining their properties in aqueous solutions at low concentrations.
- The research employs techniques like potentiometric titration and spectroscopy to analyze the complexes' fluorescence, stability, and how pH affects these factors involving coordination with nitrogen, sulfur, and oxygen atoms.
- The results indicate these complexes may have promising future applications in biomedicine, particularly as potential antibacterial and anticancer agents, suggesting a need for further research.
A comparative study on the clinical efficacy and pregnancy outcomes of methimazole and propylthiouracil in managing pregnancy complicated with hyperthyroidism.
Afr J Reprod Health
October 2024
Gynecology and obstetrics, Taizhou Women and Children's Hospital of Wenzhou Medical University, TaiZhou, 318000, China.
The objective of the study was to compare the clinical efficacy and pregnancy outcomes of methimazole and propylthiouracil in managing hyperthyroidism during pregnancy. This retrospective analysis included 100 pregnant women with hyperthyroidism, who were divided into two groups: the methimazole group (Group A) and the propylthiouracil group (Group B). Indicators such as thyroid function, liver function, pregnancy outcomes, and newborn health were closely monitored.
View Article and Find Full Text PDFKinetics of tautomerisation of thiouracils and cognate species at low temperatures: theory experiment.
Phys Chem Chem Phys
December 2024
School of Biological and Chemical Sciences, University of Galway, Galway, H91 TK33, Ireland.
Hydrogen-atom tunnelling is an important component in some chemical reactions particularly at low temperatures ≤300 K. Recent experiments by Rostkowska [H. Rostkowska, L.
View Article and Find Full Text PDFThe P300-ARRDC3 axis participates in maternal subclinical hypothyroidism and is involved in abnormal hepatic insulin sensitivity in adult offspring.
Heliyon
November 2024
Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou City, 215006, Jiangsu, China.
Article Synopsis
- Maternal subclinical hypothyroidism (SCH) may negatively affect the metabolic health of offspring, and this study created a mouse model to explore the mechanisms behind this issue.
- Increased expression of the protein ARRDC3 in the offspring's livers was linked to insulin resistance, while key proteins in the insulin signaling pathway showed reduced activity, indicating disrupted glucose metabolism.
- Administering L-T4 during pregnancy was found to improve insulin sensitivity and restore normal signaling in the offspring, highlighting a potential treatment strategy to prevent metabolic issues related to maternal SCH.
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