AI Article Synopsis
- The report describes two cases of Paneth cell-like metaplasia in the prostate, found in one case of poorly differentiated carcinoma and in another case of benign hyperplasia.
- Under the microscope, these Paneth-like cells looked similar to those typically found in the small intestine and showed specific features (electron-dense granules) characteristic of Paneth cells.
- Immunohistochemical testing revealed that while these cells tested positive for prostate-specific markers, they were negative for certain enzymes, highlighting the uncertain clinical implications of this type of metaplasia, which may indicate the ability of some cells to transform into different cell types.
Article Abstract
We report two cases of Paneth cell-like metaplasia of the prostate gland, one in poorly differentiated carcinoma and the second in benign hyperplasia. By light microscopy, the Paneth-like cells were indistinguishable from Paneth cells found in the normal small intestine and ultrastructurally showed electron-dense granules typical of Paneth cells. Immunohistochemical stains were positive for prostate-specific antigen and prostatic acid phosphatase and negative for lysozyme and alpha 1-antitrypsin. The clinical significance of Paneth cell-like metaplasia is unknown and may represent an example of the multipotential metaplastic capability of actively dividing cells.
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