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Perioperative Care and Outcomes of Patients with Brain Tumors Undergoing Elective Craniotomy: Experience from an Ethiopian Tertiary-Care Hospital.
World Neurosurg
January 2024
Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington, Seattle, Washington, USA; Harborview Injury Prevention and Research Center, Harborview Medical Center, Seattle, Washington, USA. Electronic address:
Objective: To describe patients, perioperative care, and outcomes undergoing supratentorial and infratentorial craniotomy for brain tumor resection in a tertiary-care hospital in Ethiopia.
Methods: A retrospective cohort study of patients consecutively admitted between January 1, 2021, and December 31, 2021, was performed. We characterized patients, perioperative care, and outcomes.
Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability.
Anesth Analg
March 2023
From the Department of Anesthesiology and Pain Medicine, Malignant Hyperthermia Investigation Unit, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
Article Synopsis
- Patients with malignant hyperthermia (MH) can experience myopathy symptoms like muscle pain and fatigue outside of anesthesia, and oral dantrolene might help alleviate these symptoms, but high doses can cause liver damage.
- A study of 476 MH-susceptible patients showed that 164 received dantrolene, with mild to moderate side effects reported in 28% and 13% discontinuing treatment due to these effects or lack of improvement.
- Most patients (87%) adhered to the therapy and reported improvements, especially those with a history of MH, highlighting the effectiveness of dantrolene for certain patients despite some adverse effects.*
The Effects of Anesthetics and Perioperative Medications on Immune Function: A Narrative Review.
Anesth Analg
September 2021
Anesthesiology, H. Lee Moffitt Cancer Center, Tampa, Florida.
Preclinical and clinical studies have sought to better understand the effect of anesthetic agents, both volatile and intravenous, and perioperative adjuvant medications on immune function. The immune system has evolved to incorporate both innate and adaptive components, which are delicately interwoven and essential for host defense from pathogens and malignancy. This review summarizes the complex and nuanced relationship that exists between each anesthetic agent or perioperative adjuvant medication studied and innate and adaptive immune function with resultant clinical implications.
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