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Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat Infections.
Antibiotics (Basel)
January 2025
Investigadora e Investigadores por México, Consejo Nacional de Humanidades, Ciencia y Tecnología, Mexico City 03940, Mexico.
The prolonged use of antibiotics is closely related to increased infections caused by (Cdiff). Plant-origin compounds have been expanding in recent years as the best opportunity to identify new synergic therapies to combat antibiotic-associated diseases. Mexico has incredible plant biodiversity; natural compounds with antibacterial properties are an alternative treatment.
View Article and Find Full Text PDFMetabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells.
Foods
January 2025
Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Deoxynivalenol (DON), fumonisin B (FB), and zearalenone (ZEN) are typical fusarium mycotoxins that occur worldwide in foodstuffs, posing significant health hazards to humans and animals. Single and combined exposure of DON, FB, and ZEN leads to intestinal toxicity but the toxicology mechanism research is still limited. In this study, we explored the cytotoxicity effects of DON, FB, ZEN, and their combination in rat intestinal epithelial cell line 6 (IEC-6) cells.
View Article and Find Full Text PDFRepurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation.
Front Pharmacol
January 2025
Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Objective: The expanding field of hematopoietic cell transplantation (HCT) for non-malignant diseases, including those amenable to gene therapy or gene editing, faces challenges due to limited donor availability and the toxicity associated with cell collection methods. Umbilical cord blood (CB) represents a readily accessible source of hematopoietic stem and progenitor cells (HSPCs); however, the cell dose obtainable from a single cord blood unit is frequently insufficient. This limitation can be addressed by enhancing the potency of HSPCs, specifically their capacity to reconstitute hematopoiesis.
View Article and Find Full Text PDFEffects of combinations of the essential oils trans-anethole, thymol and carvacrol against larvae of the screwworm fly Cochliomyia hominivorax in vitro.
Vet Parasitol
January 2025
Laboratório de Quimioterapia Experimental em Parasitologia Veterinária (LQEPV), Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil; Departamento de Parasitologia Animal, Instituto de Medicina Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil.
This study investigated the combined effect of trans-anethole, carvacrol and thymol on third-instar larvae of C. hominivorax. For this experiment, third-stage larvae of C.
View Article and Find Full Text PDFCombined Toxicity Assessment of Deoxynivalenol and Pb on HK-2 Cells Involved in Excessive ROS-Induced Ferroptosis.
J Agric Food Chem
January 2025
Institute for Agro-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, 1000 Jingqi Road, Shanghai 201403, China.
The cocontamination of food by several mycotoxins and heavy metals poses significant health risks, and their combined toxic effects remain poorly understood. Particularly, specific studies exploring their combined impact on ferroptosis remain limited. In this work, we investigated the combined toxic effects of a mycotoxin, called deoxynivalenol (DON), and a heavy metal, called plumbum (Pb), and explored the potential mechanisms of DON and Pb co-occurrence via excessive ROS-induced ferroptosis in HK-2 cells.
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