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Optimization of Adcitmer, a Monomethyl-Auristatin E bearing antibody-drug conjugate for the treatment of CD56-expressing cancers.
J Immunother Cancer
March 2025
Team "Biologie des Infections à Polyomavirus", UMR1282, Tours, France.
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its antitumor properties in preclinical models of the rare and aggressive skin cancer Merkel cell carcinoma (MCC).The present study aims to further optimize Adcitmer to overcome the therapeutic limitations observed with previously evaluated CD56-targeting ADCs, which were partially related to toxic effects on leukocytes.
View Article and Find Full Text PDFIdentification of a target polypeptide of the CD169 receptor of bovine macrophage using a phage display peptide library.
Dev Comp Immunol
March 2025
College of Life Science & Technology, Heilongjiang Bayi Agricultural University. Daqing 163319, Heilongjiang Province, P. R. China. Electronic address:
CD169, a salivary acid adhesion receptor on macrophages, plays a crucial role in enhancing the phagocytic response to pathogenic bacteria and in antibacterial immunity. To explore its potential in targeted veterinary drug applications, we used phage display technology to biopan peptide fragments specific to CD169. After several rounds of screening, 45 phage clones were selected for ELISA testing, resulting in 21 high-affinity clones.
View Article and Find Full Text PDFEfficient production of a novel recombinant fusion protein of EIEC effector IpaD and EGFP: Biophysical characterization and functional studies.
Biochim Biophys Acta Proteins Proteom
March 2025
Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, 713209, India. Electronic address:
The conserved invasion plasmid antigen D (IpaD) protein demonstrates broad protective capabilities against bacillary dysentery caused by Enteroinvasive Escherichia coli (EIEC) and Shigella. However, the instability of the IpaD protein at room temperature limits its therapeutic potential. The stabilization and efficient production of functional recombinant proteins remain critical challenges in therapeutic and vaccine development.
View Article and Find Full Text PDFThe intestinal barrier: a pivotal role in health, inflammation, and cancer.
Lancet Gastroenterol Hepatol
March 2025
Medical Clinic 1, Department of Gastroenterology, Ludwig Demling Endoscopy Center of Excellence, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
The intestinal barrier serves as a boundary between the mucosal immune system in the lamina propria and the external environment of the intestinal lumen, which contains a diverse array of microorganisms and ingested environmental factors, including pathogens, food antigens, toxins, and other foreign substances. This barrier has a central role in regulating the controlled interaction between luminal factors and the intestinal immune system. Disruptions of intestinal epithelial cells, which serve as a physical barrier, or the antimicrobial peptides and mucins they produce, which act as a chemical barrier, can lead to a leaky gut.
View Article and Find Full Text PDFInsights on immune profile, pathogenesis and differential diagnosis of hypersensitivity pneumonitis and pulmonary sarcoidosis-A holistic review and bibliometric analysis.
Respir Investig
March 2025
Department of Biotechnology, Brainware University, Barasat, Kolkata, West Bengal, 700125, India.
Hypersensitivity pneumonitis (HP) and sarcoidosis are granulomatous interstitial lung diseases with overlapping clinical and immunological features, posing diagnostic and therapeutic challenges. This review offers a comprehensive assessment of their immune mechanisms, etiology, and pathogenesis. HP is predominantly triggered by exposure to environmental antigens, while sarcoidosis involves an exaggerated immune response to elusive antigens.
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