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Press-Fit Bone-Anchored Prosthesis for Individuals with Transtibial Amputation.
JBJS Essent Surg Tech
May 2024
Radboud University Medical Center, Nijmegen, The Netherlands.
Background: This video article describes the use of bone-anchored prostheses for patients with transtibial amputations, most often resulting from trauma, infection, or dysvascular disease. Large studies have shown that about half of all patients with a socket-suspended artificial limb experience limited mobility and limited prosthesis use because of socket-related problems. These problems occur at the socket-residual limb interface as a result of a painful and unstable connection, leading to an asymmetrical gait and subsequent pelvic and back pain.
View Article and Find Full Text PDFUnderstanding and Deterring Online Child Grooming: A Qualitative Study.
Sex Offending
February 2024
The Lucy Faithfull Foundation, Epsom, United Kingdom.
The prevalence of online child sexual grooming offenses has been on the rise, posing significant risks to children. Child sexual grooming involves sexual communication with minors. This study aims to understand motivations and pathways of individuals who have engaged in online grooming behaviour, as well as propose effective prevention and intervention strategies.
View Article and Find Full Text PDFTOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway.
Sci Rep
January 2025
Departamento Biología Experimental, Universidad de Jaén, Paraje Las Lagunillas S/N E23071, Jaén, Spain.
In this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition. Specifically, we focus on the spontaneous ability of cells to bypass or override this checkpoint, referred to as checkpoint adaptation. Some factors involved in adapting to this checkpoint are p53 and MCPH1.
View Article and Find Full Text PDF[Surgical Strategy for Pseudoarthrosis and Delayed Nerve Palsy after Osteoporotic Vertebral Fracture].
No Shinkei Geka
January 2025
Department of Neurosurgery, Juntendo University.
Osteoporotic vertebral fractures are among the most common fractures associated with osteoporosis. Approximately 80% of cases heal by fusion in the natural process without the need for surgery, and if we include the so-called "incidental vertebral body fractures," which are discovered by chance during radiography, the frequency of prolongation of back pain due to pseudoarthrosis or delayed-onset neurological deficits is low. However, the prognosis of osteoporotic vertebral fractures is affected by the number of fractured vertebrae.
View Article and Find Full Text PDFInfluence of Messa di Voce speed on vocal stability of untrained, healthy subjects.
PLoS One
January 2025
Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Munich University Hospital (LMU), Munich, Germany.
Introduction: Despite its importance in voice training, comprehensive research into sustained vowel phonation with constant pitch and increasing and decreasing loudness, the so-called Messa di Voce, is lacking. The study examines the laryngeal behavior during Messa di Voce, regarding the impact of the speed of execution on voice stability parameters.
Materials And Methods: Nine untrained, healthy subjects (5 female, 4 male) were asked to perform Messa di Voce exercises on the vowel [i:], involving a gradual increase and decrease of volume.
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