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Pathology of Red Blood Cells in Patients with SARS-CoV-2.
Biomedicines
January 2025
Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan 0014, Armenia.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with various hematological disorders. Understanding the pathology of erythrocytes (red blood cells) in coronavirus infection may provide insights into disease severity and progression. To review and analyze the general pathology of erythrocytes in patients infected with SARS-CoV-2, focusing on clinical and laboratory findings across different severity groups.
View Article and Find Full Text PDFIntroduction: Varicella-Zoster virus (VZV) is a highly contagious alpha-herpes virus. The diagnosis of chickenpox remains a difficult task especially in cases of breakthrough chickenpox, so the development of reliable laboratory tests is necessary. The simplest and most sensitive serological test for detecting antibodies in human and animal sera is the passive hemagglutination reaction (PHAR).
View Article and Find Full Text PDFCytotoxic and antibacterial activity of naturally occurring agglutinin produced from the root of Poir.
Nat Prod Res
January 2025
Bioprocess Engineering Division, Smykon Biotech, Kanniyakumari, Tamilnadu, India.
Lectins are naturally occurring agglutinins which are produced more from plants sources compared to animal sources. The present study aims to screen the potential applications of lectin isolated from the mangrove plant, Poir. This root agglutinin of showed highest HA titre with buffalo erythrocytes.
View Article and Find Full Text PDFBiomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy.
Sci Rep
December 2024
Department of Clinical Laboratory, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212002, Jiangsu, China.
Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time.
View Article and Find Full Text PDFEffects of Different Concentrations of AmB on the Unsaturated Phospholipid-Cholesterol Membrane Using the Langmuir Monolayer and Liposome Models.
Molecules
November 2024
Xi'an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device, School of Electronic Information, Xijing University, Xi'an 710123, China.
Article Synopsis
- Amphotericin B (AmB) causes toxicity to red blood cell membranes, leading to hemolysis and limiting its effective use in treating invasive fungal infections.
- The study investigated how different concentrations of AmB (5, 45, 85, and 125 μg/mL) interact with unsaturated phospholipid membranes containing cholesterol, using methods like the Langmuir model and fluorescence techniques.
- Findings revealed that as AmB concentration increases, it not only alters the organization and elasticity of the membrane but also affects the balance between hydrophobic and hydrophilic domains, particularly when concentrations exceed 85 μg/mL.
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