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Determination of optimal sedation depth in sleep endoscopy with bispectrometry and simultaneous polysomnography.
Eur Arch Otorhinolaryngol
January 2025
Sleep Disorders Center, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
Objective: In this study, we aimed to evaluate the localization and configuration of vibration and obstruction in drug-induced sleep endoscopy(DISE) in obstructive sleep apnea patients and to investigate the optimal sedation depth.
Materials And Methods: The study was conducted prospectively with 42 patients. After achieving sedation with intravenous anesthetic agents, simultaneous monitoring of the patient's bispectrometry (BIS), DISE and sleep testing with a type 2 polysomnography device were performed.
5-FU Weakens Defensive Functions of the Junctional Epithelium.
J Periodontal Res
January 2025
Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Aim: To investigate additional factors contributing to the pathophysiology of chemotherapy-induced oral mucositis and periodontitis beyond the systemic immune suppression caused by the chemotherapeutic agent 5-Fluorouracil (5-FU).
Methods: 5-Fluorouracil was topically delivered to the non-keratinized, rapidly proliferating junctional epithelium (JE) surrounding the dentition, and acts as an immunologic and functional barrier to bacterial ingression. Various techniques, including EdU incorporation, quantitative immunohistochemistry (qIHC), histology, enzymatic activity assays, and micro-computed tomographic (μCT) imaging, were employed to analyze the JE at multiple time points following topical 5-FU treatment.
CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis.
Clin Transl Med
January 2025
Allergy Center, Department of Otolaryngology, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.
Background: House dust mite (HDM) is the leading allergen for allergic rhinitis (AR). Although allergic sensitisation by inhaled allergens renders susceptible individuals prone to developing AR, the molecular mechanisms driving this process remain incompletely elucidated.
Objective: This study aimed to elucidate the molecular mechanisms underlying HDM-induced AR.
AXL: shapers of tumor progression and immunosuppressive microenvironments.
Mol Cancer
January 2025
Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
As research progresses, our understanding of the tumor microenvironment (TME) has undergone profound changes. The TME evolves with the developmental stages of cancer and the implementation of therapeutic interventions, transitioning from an immune-promoting to an immunosuppressive microenvironment. Consequently, we focus intently on the significant role of the TME in tumor proliferation, metastasis, and the development of drug resistance.
View Article and Find Full Text PDFMulti-disciplinary treatment of broncho-esophageal fistula in a high-risk single-lung patient.
J Cardiothorac Surg
January 2025
Section of Cardiothoracic Surgery, Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021, Bergen, Norway.
Background: A broncho-esophageal fistula (BEF) is a medical and surgical disaster. Treatment of BEF is often limited to palliative stent treatment that may migrate or cause erosions and tissue necrosis. Surgical repair of BEF is the only established definite treatment.
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