The results of treatment of spondylolisthesis in 72 patients by reduction with the use of Harrington rods and circumferential fusion were reported. In dysplastic spondylolisthesis 75% satisfactory results and 83.4% spinal fusions were achieved, in stenotic spondylolistheses 80% and 85% respectively. The influence of operation on sacral bone position against lumbar spine could not be accurately traced with the aid of Wiltse radiological criteria. The authors consider arthrodesis "in situ" as insufficient procedure, especially in dysplastic type of spondylolisthesis. They recommend addition of anterior fusion that retains and stabilizes reduction being limited to single motoric unit of the spine.
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ACS Sustain Chem Eng
January 2025
Department of Chemical and Biomolecular Engineering, Universidad de Cantabria, Av. Los Castros s/n, 39005 Santander, Spain.
Although membrane technology is widely used in different gas separation applications, membrane manufacturers need to reduce the environmental impact during the membrane fabrication process within the framework of the circular economy by replacing toxic solvents, oil-based polymers, and such by more sustainable alternatives. These include environmentally friendly materials, such as biopolymers, green solvents, and surfactant free porous fillers. This work promotes the use of environmentally sustainable and low toxic alternatives, introducing the novel application of cellulose acetate (CA) as a biopolymer in combination with dimethyl carbonate (DMC) as a greener solvent and different inorganic fillers (Zeolite-A, ETS-10, AM-4 and ZIF-8) prepared without the use of toxic solvents or reactants.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Certara Inc., Melbourne, VIC, Australia.
Exposure-response (ER) analyses are routinely performed as part of model-informed drug development to evaluate the risk-to-benefit ratio for dose selection, justification, and confirmation. For logistic regression analyses with binary endpoints, several exposure metrics are investigated, based on pharmacological plausibility, including time-averaged concentration to event (C). C is informative because it accounts for dose interruptions, modifications, and reductions and is therefore often compared against ER relationships identified using steady-state exposures.
View Article and Find Full Text PDFLangmuir
January 2025
State Key Laboratory of Coordination Chemistry, Key Laboratory of Mesoscopic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
The applications of machine learning (ML) in complex interfacial interactions are hindered by the time-consuming process of manual feature selection and model construction. An automated ML program was implemented with four subsequent steps: data distribution analysis, dimensionality reduction and clustering, feature selection, and model optimization. Without the need of manual intervention, the descriptors of metal charge variance (Δ) and electronegativity of substrate (χ) and metal (δχ) were raised up with good performance in predicting electrochemical reaction energies for both nitrogen reduction reaction (NRR) and CO reduction reaction (CORR) on metal-zeolites and MoS surfaces.
View Article and Find Full Text PDFJ Neuroeng Rehabil
January 2025
Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, FL, 32611, USA.
Background: Motor module (a.k.a.
View Article and Find Full Text PDFBMC Med Res Methodol
January 2025
United Kingdom Health Security Agency (UKHSA), London, UK.
Background: SIREN is a healthcare worker cohort study aiming to determine COVID-19 incidence, duration of immunity and vaccine effectiveness across 135 NHS organisations in four UK nations. Conducting an intensive prospective cohort study during a pandemic was challenging. We designed an evolving retention programme, informed by emerging evidence on best practice.
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