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Trends in Clinico-radiological and Laboratory Characteristics of All-Cause Meningoencephalitis in Western Rajasthan.
Ann Indian Acad Neurol
November 2024
Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Article Synopsis
- The study focuses on meningoencephalitis, which involves both meningitis and encephalitis, aiming to analyze the clinical features, lab tests, imaging results, and factors predicting outcomes in affected patients.
- Conducted from July 2021 to March 2023, it enrolled patients who met the case definitions for meningitis and encephalitis, tracking their mortality and health recovery over one and three months post-discharge.
- Out of 102 cases, various infectious and non-infectious causes were identified, with notable findings in cerebrospinal fluid analysis and imaging; particularly, high mortality rates were seen in fungal and rickettsial cases while patient recovery varied depending on the type of meningoencephalitis experienced
Carbon nanodots as photosensitizer in photodynamic inactivation of Rickettsia slovaca.
Photodiagnosis Photodyn Ther
December 2024
Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia. Electronic address:
Carbon quantum dots (CQDs) are promising therapeutic agent due to their pro-oxidant, antioxidant, antiviral, antibacterial, and anticancer properties when exposed to visible light irradiation. Oxidative stress in bacteria is the main reason for bacteria death after exposure to blue light photoexcited quantum dots. Herein, we present the antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane nanocomposites, hydrophilic citric acid CQDs, and combinations of CQDs with methylene blue.
View Article and Find Full Text PDFLaboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery.
Nat Commun
November 2024
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Tools for rapid identification of novel and/or emerging viruses are urgently needed for clinical diagnosis of unexplained infections and pandemic preparedness. Here we developed and clinically validated a largely automated metagenomic next-generation sequencing (mNGS) assay for agnostic detection of respiratory viral pathogens from upper respiratory swab and bronchoalveolar lavage samples in <24 h. The mNGS assay achieved mean limits of detection of 543 copies/mL, viral load quantification with 100% linearity, and 93.
View Article and Find Full Text PDFSheeppox virus genome sequences from the European outbreaks in Spain, Bulgaria, and Greece in 2022-2024.
Arch Virol
October 2024
Sciensano (Belgium), Service of 'Exotic and Vector borne diseases' (ExoVec), Groeselenberg 99, 1180, Ukkel, Belgium.
In 2022-2024, three outbreaks of sheeppox (SPP) were reported in the European Union. These occurred in Spain, Bulgaria, and Greece and had serious economic consequences due to animal losses and trade restrictions. Five sheeppox virus (SPPV) whole-genome sequences (WGSs) were determined from samples collected during these outbreaks and analyzed in the context of all other published WGSs.
View Article and Find Full Text PDFBeak and feather disease virus (BFDV) persists in tissues of asymptomatic wild Crimson Rosellas.
Commun Biol
September 2024
Centre for Integrative Ecology, Deakin University, Geelong, VIC, Australia.
Infectious diseases can drive populations and species to extinction. Beak and feather disease virus (BFDV) is a circovirus of global conservation concern that can infect all Psittaciformes and some other species. Yet some parrot species, such as Crimson rosellas (Platycercus elegans), can live successfully with high BFDV prevalence (>40%) with no clinical signs reported in infected individuals.
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