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Mechanisms and roles of hydroxychloroquine in pregnancy in rheumatic diseases.
Ann Acad Med Singap
February 2025
Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.
Introduction: Hydroxychloroquine (HCQ), originally an antimalarial drug, is currently used to treat multiple disorders, especially rheumatic diseases. Given its good efficacy and safety, HCQ is widely administered in pregnant patients. However, the safety profile of HCQ during pregnancy remains controversial due to limited research.
View Article and Find Full Text PDFVaccine to Nano-Vaccine: Novel Technique to Treat Rheumatoid Arthritis.
Curr Rheumatol Rev
March 2025
Pharmaceutical Analysis, SVKMs Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Autoimmune diseases are a class of diseases wherein the immune system of the body targets itself through autoreactive T cells and autoantibodies. Autoimmune diseases are classified as organ-specific autoimmune diseases and systemic autoimmune diseases. Organ-specific autoimmune diseases such as primary biliary cirrhosis, Hashimoto's Thyroiditis (HT), Type 1 Diabetes mellitus (T1D), and Graves' Disease (GD) are characterized by a unique immune system response to autoantigens in a single organ.
View Article and Find Full Text PDFShort Telomere Syndrome in a patient with Primary Sjögren's Syndrome related Interstitial Lung Disease.
Am J Med Sci
March 2025
Lung Transplant and ECMO Program, Department of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, Florida, USA. Electronic address:
Interstitial lung disease (ILD) is a known complication of Primary Sjögren's syndrome (SS). We report the case of a 56-year-old man with a history of SS (SS-A positive) who was admitted with ILD exacerbation, causing respiratory failure requiring extracorporeal life support. Given the family history of rapidly progressive ILD and mixed connective tissue disease in his brother, the patient was tested for short telomere syndrome (STS) during hospitalization and found to have leukocyte telomere length (LTL) around the first percentile, suggesting the diagnosis of STS.
View Article and Find Full Text PDFM6A Modified miR-31-5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7.
Adv Sci (Weinh)
March 2025
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China.
The dysregulation of the M1/M2 macrophage balance plays a pivotal role in autoimmune diseases. However, the interplay between microRNAs (miRNAs) and N6-methyladenosine (m6A) modulation in regulating this balance remains poorly understood. Here, a significant reduction in miR-31-5p levels is observed in the lacrimal glands of rabbit autoimmune dacryoadenitis and the peripheral blood mononuclear cells (PBMCs) of Sjögren's syndrome (SS) dry eye patients.
View Article and Find Full Text PDFThe relationship between connective tissue disease and autoantibody positivity in pneumoconiosis cases.
Medicine (Baltimore)
March 2025
Occupational Diseases Clinic, Eskişehir City Hospital, Eskişehir, Turkey.
This correlation has been studied since the 1930s, and it is believed that exposure to silica can lead to various autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis. The exact mechanisms behind this link remain unclear. This study aimed to evaluate the prevalence of connective tissue diseases (CTD) and positive autoantibodies in pneumoconiosis patients and the association between radiological categorization and autoantibodies.
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