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Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats.
Curr Neuropharmacol
January 2025
Department of Pharmacology, School of Medicine University of Zagreb, Zagreb, Croatia.
This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia, and hyperlithemia. In hyperkalemia, BPC 157 demonstrated a comprehensive counteractive effect against KCl overdose (intraperitoneally, intragastrically, and in vitro), effectively mitigating symptoms such as muscular weakness, hypertension, sphincter dysfunction, arrhythmias, and lethality. It also counteracted the adverse effects of succinylcholine and magnesium overdose, including systemic muscle paralysis, arrhythmias, and hyperkalemia.
View Article and Find Full Text PDFIntubation Practices in Community Emergency Departments.
Ann Emerg Med
January 2025
Department of Emergency Medicine, Kaiser Permanente San Diego Medical Center, San Diego, CA.
Study Objective: This study analyzes emergency medicine airway management trends and outcomes among community emergency departments.
Methods: A multicenter, retrospective chart review was conducted on 11,475 intubations from 15 different community emergency departments between January 1, 2015, and December 31, 2022. Data collected included patient's age, sex, rapid sequence intubation medications, use of cricoid pressure, method of intubation, number of attempts, admission diagnosis, and all-cause mortality rates.
Succinylcholine use in Patients 8 Years and Younger is NOT Zero While Midazolam use in Patients 65 Years and Older is NOT Decreasing Anymore: A 14-Year Census Report from a Tertiary Care Medical Center in the United States.
Ann Card Anaesth
January 2025
Department of Anesthesiology, Wayne State University/Detroit Medical Center, Detroit, Michigan, United States.
Calixarene-Based Magnetic Nanosponge Decorating AgNPs for Rapid and Selective Surface-Enhanced Raman Scattering Analysis in Complex Samples.
Anal Chem
January 2025
School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
Rapid and accurate analysis of trace targets in complex samples remains an enormous challenge. Herein, the calix[]arene-based magnetic cross-linked polymer decorating AgNPs, abbreviated FeO-CXA-DAB@AgNPs nanosponge, was developed for fast surface-enhanced Raman scattering (SERS) analysis in complex samples. The FeO-CXA-DAB@AgNPs nanosponge surface was constructed by high-density CXA units with special cavity size and structure, which could selectively recognize and enrich targets to the sensing surface by the host-guest effect and molecule interactions.
View Article and Find Full Text PDFSkeletal Muscle Relaxants and Their Impact on Intracranial Pressure in Neurosurgery.
Med Sci Monit
January 2025
Department of Rheumatology, University Clinical Hospital No. 1 Szczecin, Szczecin, Poland.
Skeletal muscle relaxants have their place in everyday use in numerous anesthesiological procedures, such as preparing a patient for surgery, supporting mechanical ventilation, and performing effective intubation. These drugs can be divided, based on their mechanism of action, into depolarizing skeletal relaxants, such as succinylcholine, and non-depolarizing skeletal muscle relaxants. Non-depolarizing agents are further categorized, based on their structure, into steroidal (eg, rocuronium) and benzylisoquinoline (eg, atracurium) compounds.
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