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The antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.
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Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China.
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A randomized double-blind clinical trial investigating the effects of ellagic acid on glycemic status, liver enzymes, and oxidative stress in patients with non-alcoholic fatty liver disease.
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Department of Nutrition, Qazvin University of Medical Sciences, Qazvin, Iran.
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View Article and Find Full Text PDFBetulinic acid from Inonotus obliquus ameliorates T2DM by modulating short-chain fatty acids producing bacteria and amino acids metabolism in db/db mice.
J Ethnopharmacol
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National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China; Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address:
Ethnopharmacological Relevance: Inonotus obliquus has also been used as a traditional folk medicine in Europe and Northeastern China to treat metabolic diseases. Betulinic acid (BA) is a major ingredient with anti-diabetic property derived from I. obliquus, however, its bioavailability is limited.
View Article and Find Full Text PDFBifunctional chimeras of myeloperoxidase and glucose oxidase. Antimicrobial, topological and enzymatic properties.
J Biotechnol
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CNRS, University of Bordeaux, CRPP, UMR5031, 115 Avenue Schweitzer, F-33600 Pessac, France.
Enhancing the local substrate concentration is a crucial strategy in nature for facilitating the proximity of two enzymes. The substrate of the first enzyme is transformed into a by-product that travels to the active site of the second enzyme without external diffusion, then transformed into a product and eventually expelled from the complex. In an effort to optimize the antimicrobial properties of myeloperoxidase from Rhodopirellula baltica (RbMPO), we created a library of fused chimeras between a glucose oxidase (GOx) and RbMPO so that HO could be continuously perfused in the vicinity RbMPO, enabling the production of HOCl or HOSCN, well-known antimicrobial agents.
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