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http://dx.doi.org/10.1056/NEJM196109282651305DOI Listing

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Article Synopsis
  • Gitelman syndrome (GS) is a rare inherited disorder that causes low potassium levels, metabolic alkalosis, low calcium in urine, and high magnesium in urine, often leading to symptoms like muscle weakness and convulsions, typically appearing in late childhood or young adulthood.
  • A case study of a 16-year-old pregnant woman revealed that she experienced severe abdominal pain, weakness, and vomiting during her first trimester, and tests showed low potassium and magnesium levels, leading to a diagnosis of GS.
  • Throughout her pregnancy, she required potassium supplementation due to consistently low levels, highlighting the need for better management protocols for pregnant women with GS, as these cases are uncommon.
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Celiac crisis (CC) is a rare complication of celiac disease (CD), usually observed in younger children with unrecognized CD or poor compliance with a gluten-free diet (GFD). We present a case of celiac crisis in a 3-year-old girl who was recently diagnosed with celiac disease. She was referred to our clinic with anasarca, tetany, and severe malnutrition, with hypokalemia, hypocalcemia, hypomagnesemia, and hypoalbuminemia.

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Article Synopsis
  • * Long-term PPI use has been linked to electrolyte imbalances, particularly hypomagnesemia, but also hypokalemia and hypocalcemia, which may result from gastrointestinal or renal losses.
  • * A case study highlights a patient with severe hypomagnesemia due to PPI use combined with gastrointestinal losses, leading to serious symptoms like tetany and arrhythmias.
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Primary intestinal lymphangiectasia (PIL) is a rare disorder in children causing protein-losing enteropathy. Vitamin D deficiency and hypomagnesemia contributed to the tetany. The literature review reflects the importance of screening for these deficiencies and regular serum magnesium monitoring in PIL cases with neuromuscular or ionic abnormalities.

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