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The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure.
Physiol Rep
November 2024
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Article Synopsis
- - Recent research has found that intrapulmonary bronchopulmonary anastomoses (IBAs) create common right-to-left shunts in the lungs and may significantly influence heart failure's pathophysiology.
- - The study involved 237 heart failure patients and assessed the relationship between mixed venous oxygen saturation (SvO₂) and various pulmonary pressures, finding that lower SvO₂ levels correlate with increased pulmonary artery systolic pressure (sPAP) and pulmonary artery wedge pressure (PAWP).
- - Results indicate that decreased SvO₂ is linked to increased sPAP and PAWP, likely due to IBAs, while left ventricular end-diastolic pressure (LVEDP) did not show a
Constructing the cGAMP-Aluminum Nanoparticles as a Vaccine Adjuvant-Delivery System (VADS) for Developing the Efficient Pulmonary COVID-19 Subunit Vaccines.
Adv Healthc Mater
December 2024
School of Pharmacy, Anhui Medical University, 81 Plum Hill Road, Hefei, Anhui Province, 230032, China.
The cGAMP-aluminum nanoparticles (CAN) are engineered as a vaccine adjuvant-delivery system to carry mixed RBD (receptor-binding domain) of the original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variant for developing bivalent pulmonary coronavirus disease 2019 (COVID-19) vaccines (biRBD-CAN). High phosphophilicity/adsorptivity made intrapulmonary CAN instantly form the pulmonary ingredient-coated CAN (piCAN) to possess biomimetic features enhancing biocompatibility. In vitro biRBD-CAN sparked APCs (antigen-presenting cells) to mature and make extra reactive oxygen species, engendered lysosome escape effects and enhanced proteasome activities.
View Article and Find Full Text PDFRepercussions of SARS-CoV-2 infection on intrapulmonary shunt in patients undergoing one-lung ventilation.
J Cardiothorac Surg
September 2024
Department of Anesthesiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, China.
Article Synopsis
- The study examines how previous SARS-CoV-2 infections impact intrapulmonary shunt during one-lung ventilation (OLV) in patients undergoing thoracoscopic partial pneumonectomy.
- It included 80 patients divided into four groups: those without SARS-CoV-2 infection and those infected at various intervals post-infection (5-8 weeks, 9-12 weeks, and 13-16 weeks).
- Results showed that patients in the infected groups experienced higher intrapulmonary shunt and lower oxygen levels compared to the non-infected group during different phases of ventilation, suggesting impaired pulmonary function related to the infection.
Safety and efficacy of a novel transbronchial radiofrequency ablation system for lung tumours: One year follow-up from the first multi-centre large-scale clinical trial (BRONC-RFII).
Respirology
January 2025
State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory, Guangzhou Institute of Respiratory Disease, Guangzhou, Guangdong, People's Republic of China.
Background And Objective: Radiofrequency ablation (RFA) is an emerging treatment of lung cancer, yet it is accompanied by certain safety concerns and operational limitations. This first multi-centre, large-scale clinical trial aimed to investigate the technical performance, efficacy and safety of an innovative transbronchial RFA system for lung tumours.
Methods: The study enrolled patients with malignant lung tumours who underwent transbronchial RFA using an automatic saline microperfusion system between January 2021 and December 2021 across 16 medical centres.
Treatment of Extraneural Metastases of Myxopapillary Ependymomas With Dose-Dense Temozolomide and Lapatinib.
Cureus
August 2024
Neurology, Medical College of Wisconsin, Milwaukee, USA.
Myxopapillary ependymomas (MPEs) are rare tumors of the central nervous system, and outcomes are generally worse with recurrent disease. These tumors can rarely metastasize outside the neuraxis. We present a case of a 35-year-old female with a history of MPEs who developed extraneural metastases 11 years after her initial gross total resection.
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