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Enhanced fluorimetric detection of diphenylpyraline HCl using micelle and cyclodextrin mediated approach: Spectrofluorimetric and micellar liquid chromatographic application for either single or combined formulation with caffeine and paracetamol.
Spectrochim Acta A Mol Biomol Spectrosc
April 2023
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, The Medical Campus of Tanta University, Elgeish Street, Tanta 31111, Egypt. Electronic address:
Highly sensitive micellar spectrofluorimetric method (Method I) has been developed and validated for the determination of diphenylpyraline HCl in pharmaceutical tablets and in plasma. Sodium dodecyl sulfate improves the intensity of fluorescence of diphenylpyraline at 286 nm at pH 5 that allow its determination in plasma at nano-level. the mean percent recovery ± S.
View Article and Find Full Text PDFApplication of dummy molecularly imprinted solid-phase extraction in the analysis of cyproheptadine in bovine urine.
J Sep Sci
May 2009
Department of Analytical Chemistry, Nutrition, and Bromatology, Campus Lugo, Santiago de Compostela University, Lugo, Galiza.
Due to the difficulty of monitoring trace levels of cyproheptadine (CYP) residues in complicated biological matrices, specific adsorption materials for the preconcentration and clean-up of CYP are indispensable. In this work, CYP was extracted from urine using dummy molecularly imprinted SPE (DMISPE) to avoid leakage of the imprinting molecules during the desorption phase. For synthesis of DMISPE, azatadine (AZA) was employed as the dummy template, methacrylic acid (MAA) as the monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, 2,2'-azobis(2-methylpropionitrile) (AIBN) as the initiator, and dichloromethane as the porogen solvent.
View Article and Find Full Text PDFSimultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC.
J Pharm Biomed Anal
December 2000
Department of Pharmaceutical Analysis and Drugs Testing Laboratory, J.S.S. College of Pharmacy, Ootacamund, Tamilnadu, India.
A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitrile-triethylamine (pH adjusted to 3.5 using orthophosphoric acid; 0.
View Article and Find Full Text PDFThirteen antihistaminic drugs and their analogues are tested for their extraction by headspace solid-phase microextraction from human whole blood and urine. Their determination is made by using capillary gas chromatography with flame ionization detection. Relatively high recoveries are obtained for terodiline, diphenhydramine, diphenylpyraline, and orphenadrine in urine; but the recoveries in blood extracts are 4-51 times lower than those in urine extracts for all drugs.
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