Results from a 28-day adult reproductive bioassay using the aquatic oligochaete Tubifex tubifex (Müller, 1774) are compared with life table statistics obtained from a 6-month experiment on cohorts of the same species. This was done by simultaneously performing the two tests on copper spiked sediments. Five concentrations and a control were tested. The 28-day bioassay was performed 3 times in succession. Several endpoints were considered for each test and LOEC, IC10 and IC50 were calculated. IC50 estimates for the number of young produced in the 28-day bioassay range from 81 to 107 mg/kg; IC50 estimates for different endpoints of the cohort experiment ranged from 88 to 106 mg/kg. The 28-day bioassay showed essentially the same sensitivity as the cohort experiment to copper. This suggests that the 28-day reproductive bioassay does provide information that is relevant in assessing long-term toxic effects at the population level.
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http://dx.doi.org/10.1016/s0166-445x(03)00136-x | DOI Listing |
Cancer Gene Ther
January 2025
Reproductive Medical Center/Hubei Medical Clinical Research Center for Assisted Reproductive Technology and Embryonic Development, Renmin Hospital of Wuhan University, Wuhan, China.
Cervical cancer (CC) is a prevalent gynecological malignancy. Increasing evidence suggests that circular RNAs (circRNAs) play a pivotal role in the pathogenesis of CC. However, the regulatory function of circ_ASH1L in CC remains elusive.
View Article and Find Full Text PDFArch Environ Contam Toxicol
December 2024
ExxonMobil Biomedical Sciences, Inc., 1545 US Highway 22 East, Annandale, NJ, 08801-3059, USA.
Environmental risk assessments of very hydrophobic organic compounds (VHOCs) in soils are often difficult because multiple processes (e.g., sorption, volatilization, biodegradation) can complicate the interpretation of results.
View Article and Find Full Text PDFPorcine circovirus type 2 (PCV2) is the major causative agent of postweaning multisystemic wasting syndrome which leads to significant economic losses in the global swine industry. In China, there is a widespread dissemination of PCV2 infection in the pig population. Serological diagnosis of the disease is considered as an effective control measure.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
December 2024
Reproductive Medicine Center, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Objective: To explore the biological relationship between the regulatory signal pathways involved in differentially expressed genes and recurrent spontaneous abortion (RSA) by analyzing the gene expression microarray data of unexplained RSA.
Methods: The gene expression profile data of chorionic villi from unexplained recurrent abortion with normal karyotype and selective induced abortion were compared. Differentially expressed genes were analyzed by the "Limma" package in R Studio, and Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were carried out with "Cluster Profiler" and "org.
Bioelectrochemistry
December 2024
Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
The concentration variation of luteinizing hormone (LH) regulates the cell cycle of oocyte meiosis and significantly affect the whole reproductive cycle. Sensitively quantifying the LH biomarker therefore plays an important role for reproductive disease diagnosis. By coupling a new low background catalytic redox recycling strategy with hybridization chain reaction (HCR), we propose a highly sensitive bio-electrochemical aptamer LH sensing method.
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