Eleven new derivatives of chelidonine I, obtained by functionalization of the alkaloid hydroxyl group, have been tested for CNS activity in mice exhibiting statistically significant effects.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Development of a predictive nomogram for postoperative acute respiratory distress syndrome in Stanford type A aortic dissection patients: a retrospective study.
Rev Port Cardiol
January 2025
Department of Cardiovascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China. Electronic address:
Introduction And Objectives: This retrospective study aimed to develop a nomogram to predict the risk of postoperative acute respiratory distress syndrome (ARDS) in patients with Stanford type A acute aortic dissection.
Methods: The study included patients who underwent surgical repair for Stanford type A acute aortic dissection between January 2020 and December 2023. Demographic data, surgical details, intraoperative information, and postoperative outcomes were collected.
LoVE4MUM Mobile App to Prevent Postpartum Depression: Protocol for a Pilot Randomized Controlled Trial.
JMIR Res Protoc
January 2025
Department of Public Health Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.
Background: Postpartum depression remains a significant concern, posing substantial challenges to maternal well-being, infant health, and the mother-infant bond, particularly in the face of barriers to traditional support and interventions. Previous studies have shown that mobile health (mHealth) interventions offer an accessible means to facilitate early detection and management of mental health issues while at the same time promoting preventive care.
Objective: This study aims to evaluate the effectiveness of the Leveraging on Virtual Engagement for Maternal Understanding & Mood-enhancement (LoVE4MUM) mobile app, which was developed based on the principles of cognitive behavioral therapy and psychoeducation and serves as an intervention to prevent postpartum depression.
Preliminary investigation of an artificial intelligence-based cognitive behavioral therapy training tool.
Psychotherapy (Chic)
January 2025
Lyssn.io, Inc.
We developed an asynchronous online cognitive behavioral therapy (CBT) training tool that provides artificial intelligence- (AI-) enabled feedback to learners across eight CBT skills. We sought to evaluate the technical reliability and to ascertain how practitioners would use the tool to inform product iteration and future deployment. We conducted a single-arm 2-week field trial among behavioral health practitioners who treat outpatients with psychosis.
View Article and Find Full Text PDFShort-term mentalization-based therapy for common childhood mental disorders - a pilot quasi-randomised controlled trial.
Clin Child Psychol Psychiatry
January 2025
Department of Psychology, Stockholm University, Sweden.
Internalizing and externalizing psychiatric disorders among children are common and debilitating, affecting family interactions, learning and peer relations. The aim of the present quasi-randomised pilot-study was to investigate preliminary effects of a mentalization-based time-limited treatment (MBT-C) for children with mixed psychiatric disorders. The trial comprised 17 children, aged 4-11 with mixed disorders, and their parents, admitted to an outpatient psychotherapy clinic.
View Article and Find Full Text PDFToday, most research evaluation frameworks are designed to assess mature projects with well-defined data and clearly articulated outcomes. Yet, few, if any, are equipped to evaluate the promise of early-stage research, which is inherently characterized by limited evidence, high uncertainty, and evolving objectives. These early-stage projects require nuanced assessments that can adapt to incomplete information, project maturity, and shifting research questions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!