Clinical ethics is a practical discipline that proposes a structured approach for identifying, analyzing and resolving ethical problems in health care. Mechanical ventilation is usually administered in clinical situations that can provoke ethical conflicts. To resolve these conflicts, in each case four aspects should be analyzed: Medical indications, patient and family preferences, quality of life, and contextual features (social, economic, legal, and administrative).
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In Vitro Analysis of Enamel Abrasion Using a Novel Manual Nano-Bristle Toothbrush: An Atomic Force Microscopy Study.
Cureus
December 2024
Periodontology, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, Chengalpattu, IND.
Introduction: To evaluate the enamel abrasion effects of soft, ultra-soft, and nano-bristle toothbrushes using atomic force microscopy (AFM) to guide toothbrush selection for optimal enamel preservation.
Methods: This in vitro study involved 45 extracted human teeth (central and lateral incisors), randomly assigned to three groups (n=15 each): Group I (nano-bristle), Group II (ultra-soft bristle), and Group III (soft bristle). Each specimen underwent 10,000 brushing cycles with a standardized 2 N force to simulate one year of brushing.
Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration.
J Biol Eng
January 2025
Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan.
Bone defects present a significant challenge in orthopedics and trauma surgery, necessitating innovative approaches to stimulate effective bone regeneration. This study investigated the potential of lithium-doped calcium silicate (LiCS) cement to enhance bone regeneration and modulate the immune microenvironment to promote tissue repair. We synthesized a LiCS ceramic powder and performed comprehensive analyses of its physicochemical properties, including phase composition, morphology, setting time, and mechanical strength.
View Article and Find Full Text PDFComparative study of torque expression and its biomechanical effects: spherical self-ligating bracket with lock-hook system versus passive self-ligating bracket and conventional bracket.
BMC Oral Health
January 2025
Department of Stomatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Background: Proper torque control is crucial to the outcome of orthodontic treatment. This study aimed to employ finite element analysis to compare the torque capabilities of a novel spherical self-ligating bracket with a lock-hook system against those of commonly used passive self-ligating and conventional bracket systems, as well as to reveal the biomechanical changes in the periodontal ligament (PDL) during torque expression.
Methods: A maxillary right central incisor, along with its PDL and alveolar bone, were modeled.
Pentraxin 3: a novel biomarker in pediatric central nervous system infections.
BMC Pediatr
January 2025
Department of Pediatrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Background: Pediatric CNS infections have been identified as a global health problem, associated with an increased death rate and fatal consequences. Pentraxin 3 (PTX3) is an acute-phase mediator that increases in body fluids and plasma throughout inflammation. Our study was designed to assess the diagnostic and prognostic value of cerebrospinal fluid (CSF) PTX3 levels in pediatric patients with different central nervous system (CNS) infections.
View Article and Find Full Text PDFPediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface.
Cardiovasc Eng Technol
January 2025
School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, Rm. 718, Philadelphia, PA, 19104, USA.
Purpose: Computational models of the cardiovascular system continue to increase in complexity. As more elements of the physiology are captured in multiscale models, there is a need to efficiently integrate subsystems. The objective of this study is to demonstrate the effectiveness of a coupling methodology, called functional mock-up interface (FMI), as applied to multiscale cardiovascular modeling.
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