The aim of this paper is to present the up to date literature review on neurosyphilis and its psychopathological implications. The authors briefly describe the history of lues, its aetiology with pathomechanisms, epidemiology, clinical aspects with the emphasis on the CNS, coincidence with HIV infection, groups of risk, diagnostic aspects of lues and the therapy. The authors' intention is to stress the importance of lues in clinical differentiation in today's psychiatric practice since it happens to be omitted in the course of the diagnostic process.

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