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Front Hum Neurosci
December 2024
Ph.D. Program in Speech-Language-Hearing Sciences, The Graduate Center, The City University of New York Graduate Center, New York, NY, United States.
Introduction: Lateral temporal neural measures (Na and T-complex Ta and Tb) of the auditory evoked potential (AEP) index auditory/speech processing and have been observed in children and adults. While Na is already present in children under 4 years of age, Ta emerges from 4 years of age, and Tb appears even later. The T-complex has been found to be sensitive to language experience in Spanish-English and Turkish-German children and adults.
View Article and Find Full Text PDFThe emergence of parasites partially resistant to artemisinins (ART-R) poses a significant threat to recent gains in malaria control. ART-R has been associated with PfKelch13 (K13) mutations, which differ in fitness costs. This study investigates the gametocyte production and transmission fitness of African and Asian isolates with different K13 genotypes across multiple mosquito species.
View Article and Find Full Text PDFUnlabelled: Understanding the evolution of cancer in its early stages is critical to identifying key drivers of cancer progression and developing better early diagnostics or prophylactic treatments. Early cancer is difficult to observe, though, since it is generally asymptomatic until extensive genetic damage has accumulated. In this study, we develop a computational approach to infer how once-healthy cells enter into and become committed to a pathway of aggressive cancer.
View Article and Find Full Text PDFFront Cell Dev Biol
December 2024
School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Polo-like kinase 1 (PLK1), a key regulator of the G2/M phase in mitosis, is frequently overexpressed in numerous tumors. Although PLK1 inhibitors have emerged as promising therapeutic agents for cancer, their use has been linked to significant anemia in a subset of patients, yet the underlying mechanisms remain poorly understood. In this study, we utilized an human umbilical cord blood-derived CD34 cell-based erythroid differentiation system, alongside a murine model, to investigate the impact of PLK1 inhibitors on erythropoiesis.
View Article and Find Full Text PDFJBI Evid Synth
January 2025
School of Occupational Therapy, Touro University Nevada, Henderson, Nevada.
Objective: The proposed scoping review aims to explore the literature on the use of acceptance and commitment therapy (ACT) by occupational therapy (OT) practitioners, including how OT practitioners use ACT in the evaluation or intervention process, what types of client concerns they are addressing through ACT, in what settings they are using ACT, and what outcomes are being reported.
Introduction: ACT is a third-wave cognitive behavioral therapy that is effective across a wide range of diagnoses commonly seen by OT practitioners. Given the increased use of ACT by OT practitioners, a comprehensive understanding of its use in clinical practice would benefit OT practitioners, referring health care providers, and clients, as well as informing future research.
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