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Endosymbionts are important for insect species as they provide essential substances to the host. Due to the technical advance of NGS technology and assemblers, many endosymbionts bacterial genomes are available now. Here, we analysed fourteen endosymbiont bacterial genomes of genius, one of notorious pest species.

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Endothelial Dysfunction Markers in Ovarian Cancer: VTE Risk and Tumour Prognostic Outcomes.

Life (Basel)

December 2024

Molecular Oncology and Viral Pathology Group, Research Centre of IPO Porto (CI-IPOP), Pathology and Laboratory Medicine Department, Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto. CCC), 4200-072 Porto, Portugal.

Ovarian cancer (OC) presents daunting lethality rates worldwide, with frequent late-stage diagnosis and chemoresistance, highlighting the need for improved prognostic approaches. Venous thromboembolism (VTE), a major cancer mortality factor, is partially driven by endothelial dysfunction (ED). ED's pro-inflammatory state fosters tumour progression, suggesting a VTE-independent link between ED and cancer.

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Background/aim: Oral cancer (OC) is the leading cause of fatalities in Pakistan among males due to inadequate oral hygiene and chewing habits. However, genetic susceptibility patterns also play a critical role in disease progression. Since the frequency of Resistin (RETN) SNP (Single nucleotide polymorphism) rs3219175 is unknown; there is a requirement for early diagnosis of the OC.

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Article Synopsis
  • The study aimed to determine if herpes virus infections (CMV, EBV, HSV, and VZV) cause allograft dysfunction after organ transplantation, using a method called Mendelian randomization.
  • Findings indicated that higher levels of EBV early antigen-D antibodies and shingles are linked to increased allograft dysfunction risk, while no significant evidence supported that allograft dysfunction increases herpes virus infections.
  • The results suggest a possible involvement of EBV and VZV in graft rejection; however, the influence of CMV and HSV on allograft dysfunction needs further investigation.
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