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A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
Skin Appendage Disord
December 2024
Centre de Santé Sabouraud, Hôpital Saint Louis, Paris, France.
Introduction: Scalp seborrheic dermatitis (SSD) is a chronic, relapsing, and inflammatory condition impacting quality of life (QoL). This study evaluated the efficacy and impact on QoL of a 1% selenium disulphide-containing shampoo (SeS shampoo) compared to a 2% ketoconazole shampoo.
Methods: This multi-centric, double-blinded, randomized 4-week study was conducted in 64 adult subjects with moderate to severe SSD (SSD severity score (SSSD) > 6).
Pemphigus Vulgaris Mimicking Seborrheic Dermatitis: A Case Report.
Cureus
October 2024
Dermatopathology, Institute for Immunofluorescence, Pompano Beach, USA.
This case discusses a 55-year-old patient who was evaluated at a dermatology outpatient clinic for a chronic, pruritic, and painful hyperkeratotic plaque located on her scalp vertex. Given the size of the plaque and its thick, yellow scales, an initial clinical diagnosis of seborrheic dermatitis was favored. However, after weeks of unsuccessful treatment with ketoconazole shampoo, topical fluocinolone 0.
View Article and Find Full Text PDFA New Purpose to Old Arsenal: Exploring the Safety and Efficacy of a New Regimen Comprising a Combination of Chlorhexidine Gluconate and Cetrimide for Seborrheic Dermatitis Treatment in a Randomized Placebo-Controlled Clinical Trial.
Cureus
September 2024
Savlon Swasth India Mission, ITC Life Sciences and Technology Centre, Bangalore, IND.
Background: Seborrheic dermatitis is a common scalp condition affecting the quality of life of individuals across all age groups. The uninhibited proliferation of and enhanced sebaceous gland activity often leads to scalp flaking, mild erythema, and itching, thereby worsening the situation. Here, we aimed to study the efficacy of an antiseptic liquid as a pre-shampoo rinse followed by a non-anti-dandruff shampoo as a dandruff care strategy.
View Article and Find Full Text PDFKetoconazole Shampoo for Seborrheic Dermatitis of the Scalp: A Narrative Review.
Cureus
August 2024
Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, USA.
Article Synopsis
- Seborrheic dermatitis (SD) is a common inflammatory skin condition that causes itchy, greasy, flaky patches, particularly on the scalp, and can significantly impact a person's quality of life.
- Ketoconazole shampoo is an effective topical antifungal treatment for scalp seborrheic dermatitis (SSD), showing significant improvements in irritation and scaling in patients during various clinical trials.
- The studies indicate that ketoconazole shampoo has low relapse rates and minimal side effects, making it a safe and reliable option for patients seeking relief from SSD.
Scalp microbiome: a guide to better understanding scalp diseases and treatments.
Arch Dermatol Res
July 2024
Wake Forest School of Medicine Department of Dermatology, Winston-Salem, NC, USA.
Article Synopsis
- The scalp microbiome consists of various microorganisms that help maintain scalp health and control inflammation, but dysregulation can lead to conditions like alopecia areata, dandruff, scalp psoriasis, and folliculitis.
- Research shows different microbial populations are linked to specific scalp conditions, with certain bacteria and fungi being more prevalent in patients compared to healthy individuals.
- Treatment options typically involve antifungals, but emerging alternatives, such as coconut oils and shampoos with probiotics, may help restore a healthy scalp microbiome and improve symptoms.
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