Extending the chemistry of enzymes and abzymes.

Trends Biotechnol

Department of Chemistry, Research Institute of Scripps Clinic, La Jolla, CA 92037.

Published: January 1991

Selective chemical modification can be used to create novel proteins, particularly enzymes and antibodies, with altered specificities and catalytic activities in vitro. Modification strategies now being developed should soon yield a wide spectrum of novel biomolecules whose activities are optimized for specific industrial processes or therapeutic applications.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0167-7799(91)90006-4DOI Listing

Publication Analysis

Top Keywords

extending chemistry
4
chemistry enzymes
4
enzymes abzymes
4
abzymes selective
4
selective chemical
4
chemical modification
4
modification create
4
create novel
4
novel proteins
4
proteins enzymes
4

Similar Publications

Islatravir (ISL) is a novel antiretroviral that inhibits HIV-1 reverse transcriptase translocation. The M184V mutation, known to reduce ISL's viral susceptibility in vitro, could arise from prolonged exposure to nucleoside reverse transcriptase inhibitors (NRTI) (3TC). This study evaluated the predictive efficacy of ISL and identified potentially active antiretrovirals in combination among treatment-experienced patients in Cameroon, where NRTIs (3TC) have been the backbone of ART for decades now.

View Article and Find Full Text PDF

Hydrogels of Poly(2-hydroxyethyl methacrylate) and Poly(N,N-dimethylacrylamide) Interpenetrating Polymer Networks as Dermal Delivery Systems for Dexamethasone.

Pharmaceutics

January 2025

Laboratory on Structure and Properties of Polymers, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria.

: This study is an attempt to reveal the potential of two types of interpenetrating polymer network (IPN) hydrogels based on poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(N,N-dimethylacrylamide) (PDMAM). These IPNs were evaluated for their potential for dermal delivery of the hydrophobic drug dexamethasone (DEX). : The two types of IPNs were analyzed for their rheological behavior, swelling characteristics, and drug-loading capacity with DEX.

View Article and Find Full Text PDF

Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo.

Pharmaceutics

December 2024

Department of Experimental Therapeutics, BC Cancer, Vancouver, BC V5Z 1L3, Canada.

Preclinical studies have shown that the anti-malarial drug hydroxychloroquine (HCQ) improves the anti-cancer effects of various therapeutic agents by impairing autophagy. These findings are difficult to translate in vivo as reaching an effective HCQ concentration at the tumor site for extended times is challenging. Previously, we found that free HCQ in combination with gefitinib (Iressa, ZD1839) significantly reduced tumor volume in immunocompromised mice bearing gefitinib-resistant JIMT-1 breast cancer xenografts.

View Article and Find Full Text PDF

Profiles of 71 Human Milk Oligosaccharides and Novel Sub-Clusters of Type I Milk: Results from the Ulm SPATZ Health Study.

Nutrients

January 2025

Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Liebigstr 20a, Haus 6, 04103 Leipzig, Germany.

Background/objectives: Although approximately 160 human milk oligosaccharides (HMOs) have been identified, current studies on HMO quantitation are limited to the 10-19 most abundant HMOs. We assessed the variations in the relative concentrations of 71 HMO structures over lactation in human milk samples by an advanced liquid chromatography-mass spectrometry approach.

Methods: Samples were collected from 64 mothers at 6 weeks, 6 months, and 12 months of lactation in the Ulm SPATZ Health Study, a German birth cohort.

View Article and Find Full Text PDF

Thermal modification is an environmentally friendly process that does not utilize chemical agents to enhance the stability and durability of wood. The use of thermally modified wood results in a significantly extended lifespan compared with untreated wood, with minimal maintenance requirements, thereby reducing the carbon footprint. This study examines the impact of varying modification temperatures (160, 180, and 210 °C) on the lignin of spruce wood using the ThermoWood process and following the accelerated aging of thermally modified wood.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!