We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of interleukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioactive form continuously over a 20- to 30-day period.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nbt0890-755 | DOI Listing |
Publication Analysis
Top Keywords
peg il-2
12
controlled release
8
release interleukin-2
8
il-2
6
interleukin-2 biodegradable
4
biodegradable microspheres
4
microspheres evaluated
4
evaluated biodegradable
4
biodegradable polydl-lactide-co-glycolide
4
polydl-lactide-co-glycolide microspheres
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!