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Direct Evaluation of Salivary Antioxidant Properties in Patients with Down Syndrome for assessment to Periodontal Disease and Premature Aging.
Free Radic Biol Med
January 2025
Department of Disaster Related Oral Health & Oxidative Stress/ESR Laboratories, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan. Electronic address:
To evaluate oxidative stress involved in Down syndrome periodontal disease and pathological premature aging, reactive oxygen species (ROS) such as superoxide (O) and hydroxyl radical (HO) in human saliva were measured using electron spin resonance (ESR) spectroscopy. The groups consisted of 20 subjects in the Down syndrome (DS) child (DC) group (mean age 11.3 ± 4.
View Article and Find Full Text PDFOptimal functioning of hypothalamic-pituitary-adrenal axis after cessation of prednisolone therapy: a cross-sectional study in children with nephrotic syndrome.
Pediatr Nephrol
January 2025
Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Delhi, 110031, India.
Background: Hypothalamic-pituitary-adrenal (HPA) axis recovery after cessation of steroid therapy in children with nephrotic syndrome (NS) has hardly been studied in the literature.
Methods: This 22-month cross-sectional study recruited children (2-14 years) with NS, having received a minimum 3 months of prednisolone, now in remission, and off steroids for 1, 3, or 6 months. Serum cortisol-basal and stimulated (with long-acting intramuscular adrenocorticotropic hormone), and factors affecting them, were assessed.
The Impact of Autistic Traits on Joint Attention in Young Children With Down Syndrome During Mother-Child and Father-Child Interactions.
Am J Speech Lang Pathol
January 2025
Waisman Center, University of Wisconsin-Madison.
Purpose: Joint attention predicts later language in Down syndrome (DS) and autism. The co-occurrence of autism in children with DS is 6%-19%, which is higher than in the general population. However, little is known about how co-occurring autism in DS impacts the development of joint attention.
View Article and Find Full Text PDFDisabilities and Disparities in Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis in Saudi Arabia.
Medicina (Kaunas)
December 2024
International Research Collaboration-Oral Health and Equity, School of Allied Health, The University of Western Australia, Perth, WA 6009, Australia.
: In Saudi Arabia, persons with disabilities (PWDs) face considerable oral health challenges, including a higher prevalence of dental caries and gingival inflammation, which adversely affects their oral health-related quality of life (OHRQoL). This population experiences distinct and substantial barriers in accessing adequate dental care. This systematic review and meta-analysis aims to quantify disparities in OHRQoL between PWDs and individuals without disabilities in Saudi Arabia, focusing on caries and gingivitis prevalence, and to identify specific areas for intervention.
View Article and Find Full Text PDFComparative Pacing Profile and Chronometric Performance in Elite Swimmers with Intellectual Impairments and Able-Bodied Athletes.
Life (Basel)
December 2024
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, Italy.
Pacing strategy is a complex self-regulation process, crucial for optimising sports performance. Athletes with Intellectual Impairments (IIs) face unique challenges due to cognitive limitations that may hinder their ability to pace effectively, impacting chronometric performance. This study analysed the pacing profiles and chronometric performance across 253 event entries by elite swimmers with II, divided into three groups: 100 entries for group II1 (intellectual disability), 85 for group II2 (Down syndrome), and 68 for group II3 (autism spectrum disorder).
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