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Introduction: The clinical and genetic characteristics of nephrogenic diabetes insipidus (NDI) were described via assessing 2 cases of NDI patients from a Chinese family.

Patient Concerns: Two patients who manifest polyuria and polydipsia were admitted to hospital for definite diagnosis.

Diagnosis: Water deprivation-vasopressin tests showed that the patients may possess renal-origin diabetes insipidus.

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Diuretics for respiratory distress syndrome in preterm infants.

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Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, USA, 75390-9063.

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Objective: To review the etiology, diagnosis, and management of diabetes insipidus during pregnancy.

Data Sources: A search of the literature was performed in PubMed using key word searching and citation snowballing to identify articles published in English between January 1, 1980, and December 31, 2008, on the subject of diabetes insipidus during pregnancy. Once the articles were identified, a thorough review of all results was conducted.

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The administration of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin type 1 receptor blockers (ARBs) to pregnant women has been reported to cause ACEI/ARB fetopathy, including oligohydramios, pulmonary hypoplasia, renal insufficiency, limb contracture, and fetal hypotension in the child. Most of the patients die or develop end-stage renal failure during the neonatal period. The long-term prognosis of renal dysfunctions of patients with ARB fetopathy has not been reported.

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