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Slow or fast infusion profiles for Rubidium-82-What is the fuzz about?
J Nucl Cardiol
November 2024
Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Copenhagen University Hospital - Rigshospitalet and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Fast vs slow rubidium-82 infusion profiles and test-retest precision of myocardial perfusion using contemporary 3D cardiac analog positron emission tomography-computed tomography imaging.
J Nucl Cardiol
November 2024
John Ochsner Heart and Vascular Institute, Department of Cardiovascular Diseases, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA; Ochsner Clinical School, Queensland University School of Medicine, New Orleans, LA, USA.
Background: On legacy 2D positron emission tomography (PET) systems utilizing a 50 mL/min Rb-82 profile, test-retest precision of quantitative perfusion is ∼10%. It is unclear whether Rb-82 infusion rate significantly impacts quantitative perfusion and/or image quality on modern analog 3D PET-CT systems. We aimed to determine whether the Rb-82 infusion profile significantly impacts test-retest precision of quantitative perfusion, perfusion metrics, and/or image quality on a modern analog 3D PET-CT scanner.
View Article and Find Full Text PDFThe physiological basis of renal nuclear medicine.
Nucl Med Commun
September 2024
Department of Nuclear Medicine, King's College Hospital, London, UK.
Renal physiology underpins renal nuclear medicine, both academic and clinical. Clearance, an important concept in renal physiology, comprises tissue uptake rate of tracer (tissue clearance), disappearance rate from plasma (plasma clearance), appearance rate in urine (urinary clearance) and disappearance rate from tissue. In clinical research, steady-state plasma clearances of para-amino-hippurate and inulin have been widely used to measure renal blood flow (RBF) and glomerular filtration rate (GFR), respectively.
View Article and Find Full Text PDFPulmonary blood volume measured by Rb-PET in patients with chronic obstructive pulmonary disease: a retrospective cohort study.
J Appl Physiol (1985)
May 2024
Centre for Physical Activity Research, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
In patients with chronic obstructive pulmonary disease (COPD), pulmonary vascular dysfunction and destruction are observable before the onset of detectable emphysema, but it is unknown whether this is associated with central hypovolemia. We investigated if patients with COPD have reduced pulmonary blood volume (PBV) evaluated by Rb-positron emission tomography (PET) at rest and during adenosine-induced hyperemia. This single-center retrospective cohort study assessed 6,301 Rb-PET myocardial perfusion imaging (MPI) examinations performed over a 6-yr period.
View Article and Find Full Text PDFReliability of rubidium-82 PET/CT for renal perfusion determination in healthy subjects.
BMC Nephrol
November 2022
University Clinic in Nephrology and Hypertension, Department of Medicine, Gødstrup Hospital and Aarhus University, Herning, Denmark.
Background: Changes in renal perfusion may play a pathophysiological role in hypertension and kidney disease, however to date, no method for renal blood flow (RBF) determination in humans has been implemented in clinical practice. In a previous study, we demonstrated that estimation of renal perfusion based on a single positron emission tomography/computed tomography (PET/CT) scan with Rubidium-82 (Rb) is feasible and found an approximate 5% intra-assay coefficient of variation for both kidneys, indicative of a precise method.This study's aim was to determine the day-to day variation of Rb PET/CT and to test the method's ability to detect increased RBF induced by infusion of amino acids.
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