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The links between soil and water pollution and cardiovascular disease.
Atherosclerosis
March 2025
University Medical Center Mainz, Department of Cardiology at the Johannes Gutenberg University, Germany; German Cardiovascular Research Center (DZHK), Partner Site Rhine Main, Mainz, Germany.
Soil and water pollution represent significant threats to global health, ecosystems, and biodiversity. Healthy soils underpin terrestrial ecosystems, supporting food production, biodiversity, water retention, and carbon sequestration. However, soil degradation jeopardizes the health of 3.
View Article and Find Full Text PDFThe novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis.
J Pharmacol Exp Ther
February 2025
Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Pulmonary fibrosis encompasses different chronic interstitial lung diseases, and the predominant form, idiopathic pulmonary fibrosis, remains to have a poor prognosis despite 2 approved therapies. Although the exact pathobiological mechanisms are still incompletely understood, epithelial injury and aberrant wound healing responses contribute to the gradual change in lung architecture and functional impairment. Lysophosphatidic acid (LPA)-induced lysophosphatidic receptor 1 (LPA1) signaling was proposed to be a driver of lung fibrosis, and LPA1 antagonists have shown promising antifibrotic profiles in early clinical development.
View Article and Find Full Text PDFPolyCrit: An Online Collaborative Platform for Polymer Characterization.
J Chromatogr A
March 2025
Department of Chemistry, University of Memphis, Memphis, TN, 38152, USA. Electronic address:
Polymer liquid chromatography at critical conditions (LCCC) is a chromatographic separation condition achieved by carefully balancing the interaction of a polymer with stationary and mobile phases to make the elution time of a polymer in chromatography independent of its molecular weight. By removing the dependence of elution time on polymer molecular weight, the LCCC then allows separation of polymer samples on the basis of secondary differences, such as topology, branching, and end-group functionality, that are otherwise difficult to resolve. Despite its potential, LCCC remains under-employed due to the complexity of its optimization and the scattered nature of existing data.
View Article and Find Full Text PDFThe complex role of oxytocin in fear acquisition and generalization.
Psychoneuroendocrinology
March 2025
Institution for Brain and Psychological Science, Sichuan Normal University, Chengdu 610066, China; Center for Neurogenetics, Shenzhen Institute of Neuroscience, Shenzhen 518057, China. Electronic address:
Fear is an adaptive response that protects individuals from potential threats, but when excessive, it can lead to mental health disorders such as generalized anxiety disorder. Oxytocin is a neuromodulator whose effects on fear processing have been explored, although research results are inconsistent. Previous research indicates that administering oxytocin before fear acquisition can enhance fear learning, while studies have suggested a potential for reducing fear generalization when oxytocin is given after fear acquisition.
View Article and Find Full Text PDFEvolution of intimate partner violence impacts from cash transfers, food transfers, and behaviour change communication: Mixed-method experimental evidence from a nine-year post-programme follow-up in Bangladesh.
Soc Sci Med
February 2025
London School of Hygiene and Tropical Medicine, London, United Kingdom.
Cash or food transfers can reduce intimate partner violence (IPV), but knowledge gaps remain on how impacts evolve over time, and the role of complementary 'plus' activities and contextual factors. We conducted a mixed-method analysis of how the Transfer Modality Research Initiative in Bangladesh affected IPV over time. The programme was implemented from 2012 to 2014, following a randomised controlled trial (RCT) design, across Northern and Southern Bangladesh.
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