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Successful Treatment of Non-invasive Bladder Cancer During Pregnancy: Diagnostic and Management Challenges.
Cureus
December 2024
Radiology, Fernandez Hospital, Hyderabad, IND.
Urological malignancies during pregnancy are exceedingly rare, with bladder cancer posing significant diagnostic and management challenges. This study describes a 28-year-old pregnant woman diagnosed with non-invasive papillary urothelial carcinoma, presenting with painless hematuria at 22 weeks of gestation. The diagnostic process included ultrasound and MRI, both of which confirmed a solitary polypoidal lesion.
View Article and Find Full Text PDFAtypical Oral Mucosal Lesions in Syphilis: A Case Report Highlighting the Diagnostic and Therapeutic Aspects of the "Great Imitator".
Cureus
December 2024
General and Oncological Dermatology Ward with a Day Care Unit, Provincial Hospital, Opole, POL.
The diagnostic process and discrimination of mucosal lesions present a formidable challenge for numerous clinicians, primarily attributable to the common overlap of clinical manifestations observed across various categories, including infectious, autoimmune, connective tissue, and systemic vascular inflammatory diseases. In cases of mucosal lesions, syphilis presents distinctive characteristics that can help clinicians differentiate it from other conditions. The most common manifestation of primary syphilis is mostly a painless, firm, indurated ulcer known as a chancre, which typically appears at the site of inoculation, with enlargement of regional lymph nodes.
View Article and Find Full Text PDFClinical characteristics, management, and malignancy rate of oral lichen planus: a European multicenter study.
J Stomatol Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Introduction: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous condition that includes a spectrum of oral clinical manifestations ranging from mild painless white lesions to painful erosions and ulcers. The purpose of this European multicenter study is to describe the general characteristics of OLP lesions, the clinical and histopathological diagnosis, and the management of OLP at different European Oral Medicine and Maxillofacial Surgery centers, in order to minimize selections biases and provide information about the current trends in the treatment of OLP across Europe.
Materials And Methods: Data and histopathological records of patients with OLP were retrospectives revised and only those patients that fulfilled the diagnostic criteria from the 2016 position paper by American Academy of Oral and Maxillofacial Pathology were included.
Advancements in Minimally Invasive Techniques in Pediatric Dentistry: A Review.
Cureus
January 2025
Dental Public Health, University College London, London, GBR.
Minimally invasive dentistry (MID) has revolutionized pediatric dental care by emphasizing the preservation of healthy tooth structures, reducing treatment-related trauma, and improving patient compliance. This narrative review explores advancements in MID techniques, including silver diamine fluoride (SDF), resin infiltration, atraumatic restorative treatment (ART), bioactive materials, laser-assisted therapies, and three-dimensional (3D) printing technologies. These approaches prioritize early diagnosis, prevention, and conservative management, aligning with patient-centered and sustainable practices.
View Article and Find Full Text PDFHigh-resolution whole-genome DNA methylation revealed unique signatures of painful diabetic neuropathy.
Diabetes
January 2025
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
The aim of this work was to describe the DNA methylation signature and to identify genes associated with neuropathic pain in type 2 diabetes mellitus. We analyzed two independent diabetic neuropathy cohorts: PROPGER consisting of 72 painful and 67 painless patients recruited at the German Diabetes Center in Düsseldorf (DE), and PROPENG comprising 27 painful and 65 painless diabetic neuropathy patients recruited at the University of Manchester (UK). Genome-wide methylation data was generated using Illumina Infinium Methylation EPIC v1.
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