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Ultrasensitive Characterization of Native Bacterial Biofilms via Dynamic Nuclear Polarization-Enhanced Solid-State NMR.
Angew Chem Int Ed Engl
January 2025
University of Pittsburgh School of Medicine, Structural Biology, 3501 5th Ave., Biomedical Science Tower 3, Room 2044, 15261, Pittsburgh, UNITED STATES OF AMERICA.
Bacterial biofilms are major contributors to persistent infections and antimicrobial resistance, posing significant challenges to treatment. However, obtaining high-resolution structural information on native bacterial biofilms has remained elusive due to the methodological limitations associated with analyzing complex biological samples. Solid-state NMR (ssNMR) has shown promise in this regard, but its conventional application is hindered by sensitivity constraints for unlabeled native samples .
View Article and Find Full Text PDFAdapting single-walled carbon nanotube-based thin-film transistors to flexible substrates with electrolyte-gated configurations using a versatile tri-layer polymer dielectric.
Nanoscale Adv
December 2024
Department of Chemical and Biological Engineering, University of Ottawa 161 Louis Pasteur Ottawa Ontario K1N 6N5 Canada
Flexibility has been a key selling point in the development of carbon-based electronics and sensors with the promise of further development into wearable devices. Semiconducting single-walled carbon nanotubes (SWNTs) lend themselves well to applications requiring flexibility while achieving high-performance. Our previous work has demonstrated a tri-layer polymer dielectric composed of poly(lactic acid) (PLA), poly(vinyl alcohol) with cellulose nanocrystals (PVAc), and toluene diisocyanate-terminated poly(caprolactone) (TPCL), yielding an environmentally benign and solution-processable n-type thin-film transistor (TFT).
View Article and Find Full Text PDFA mobile intervention to reduce anxiety among university students, faculty, and staff: Mixed methods study on users' experiences.
PLOS Digit Health
January 2025
Department of Psychology, University of Virginia, Charlottesville, Virginia, United States of America.
Anxiety is highly prevalent among college communities, with significant numbers of students, faculty, and staff experiencing severe anxiety symptoms. Digital mental health interventions (DMHIs), including Cognitive Bias Modification for Interpretation (CBM-I), offer promising solutions to enhance access to mental health care, yet there is a critical need to evaluate user experience and acceptability of DMHIs. CBM-I training targets cognitive biases in threat perception, aiming to increase cognitive flexibility by reducing rigid negative thought patterns and encouraging more benign interpretations of ambiguous situations.
View Article and Find Full Text PDFTechnological innovation and revolution with single-use digital flexible ureteroscopes: a review from section of EAU Endourology.
Curr Opin Urol
January 2025
Department of Urology, University Hospital Southampton NHS Trust, Southampton, UK.
Purpose Of Review: Numerous scope-related innovations have taken place in the field of endourology. The presented analytical review is aimed at studying the technical innovations of the single-use digital flexible ureteroscopes. In November 2024, a comprehensive search was done for information on latest disposable flexible digital ureteroscopes, as well as their various unique characteristics.
View Article and Find Full Text PDFA Narrative Review on the Neurocognitive Profiles in Eating Disorders and Higher Weight Individuals: Insights for Targeted Interventions.
Nutrients
December 2024
Orygen, Parkville, VIC 3052, Australia.
: Recent research has increasingly explored the cognitive processes underlying eating disorders (EDs), including anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), other specified feeding or eating disorders (OSFEDs), and individuals with higher weight (HW). This critical narrative review focuses on neurocognitive findings derived from mainly experimental tasks to provide a detailed understanding of cognitive functioning across these groups. Where experimental data are lacking, we draw on self-report measures and neuroimaging findings to offer supplementary insights.
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