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Transplantation of genome-edited retinal organoids restores some fundamental physiological functions coordinated with severely degenerated host retinas.
Stem Cell Reports
January 2025
Research Center, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan; Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan. Electronic address:
We have previously shown that the transplantation of stem cell-derived retinal organoid (RO) sheets into animal models of end-stage retinal degeneration can lead to host-graft synaptic connectivity and restoration of vision, which was further improved using genome-edited Islet1 ROs (gROs) with a reduced number of ON-bipolar cells. However, the details of visual function restoration using this regenerative therapeutic approach have not yet been characterized. Here, we evaluated the electrophysiological properties of end-stage rd1 retinas after transplantation (TP-rd1) and compared them with those of wild-type (WT) retinas using multi-electrode arrays.
View Article and Find Full Text PDFEvaluating small extracellular vesicle-based vaccination across heterologous strains isolated from wastewater.
Infect Immun
January 2025
Microbiology and Cell Science Department, IFAS, University of Florida, Gainesville, Florida, USA.
infections pose significant public health challenges worldwide. The diversity of strains, particularly those isolated from environmental and clinical sources, necessitates innovative approaches to prevention and treatment. Previous research has shown that small extracellular vesicles (sEVs) produced by macrophages during Typhimurium infection can induce robust immune responses when used as a vaccine, offering complete protection in systemic infection models.
View Article and Find Full Text PDFNeurobiological stress markers in educational research: A systematic review of physiological insights in health science education.
Trends Neurosci Educ
December 2024
Center for Medical Education, Ruhr-University Bochum, 44801 Bochum, Germany.
Background: Traditional self-reported measures in health science education often overlook the physiological processes underlying cognitive and emotional responses.
Purpose: This review aims to analyze the frequency, sensitivity, and utility of physiological markers in understanding cognitive and emotional dynamics in learning environments.
Methods: A systematic PubMed search identified 156 records, with 13 studies meeting inclusion criteria.
The unrevealed links: periodontal health, human milk composition, and infant gut microbiome dynamics.
Prim Health Care Res Dev
November 2024
Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
Aim: This review aims to identify the mechanistic relationships related to periodontal diseases and its possible association with changes in human milk composition and the composition and function of infants' gut microbiome.
Background: Maternal health conditions, especially inflammatory, are associated with altered human milk composition. It is known whether maternal oral inflammatory diseases, including periodontal diseases, deleteriously affect human milk composition.
Relationship between infant gastrointestinal microorganisms and maternal microbiome within 6 months of delivery.
Microbiol Spectr
October 2024
College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.
To investigate the association between the microbiota in mothers and gut microbiota in infants from 0 to 6 months, the microbiotas in infant feces, maternal feces, and breast milk were determined by 16S rRNA gene sequencing. The contribution of each maternal microbiome to the infant was assessed using fast expectation-maximization for microbial source tracking calculations. The levels of short-chain fatty acids (SCFAs) and secretory immunoglobulin A (sIgA) in the feces of infants were also determined using gas chromatography and IDK-sIgA ELISA to gain a more comprehensive understanding of the infant gut microbiome.
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