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Plasma-based proteomic and metabolomic characterization of lung and lymph node metastases in cervical cancer patients.
J Pharm Biomed Anal
January 2025
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; Key Laboratory for Molecular Medicine and Chinese Medicine Preparations, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. Electronic address:
Article Synopsis
- - Metastasis is a major concern in cervical cancer (CC), particularly affecting lymph nodes and lungs, leading to poor patient outcomes and limited predictive tools for determining metastasis risk.
- - The study analyzed plasma samples from CC patients with and without metastasis using advanced proteomics and metabolomics techniques, revealing common inflammatory processes and distinct metabolic changes between lung and lymph node metastasis groups.
- - Researchers identified two promising biomarker panels for predicting lung and lymph node metastasis, demonstrating strong diagnostic potential with high accuracy in both training and testing sets.
Biochemical Characterization of a New 10% IVIG Preparation [IgG Next Generation (BT595)/Yimmugo] Obtained from a Manufacturing Process Preserving IgA/IgM Potential of Human Plasma.
Drugs R D
September 2023
Biotest AG, Landsteinerstr.5, Dreieich, Germany.
Background And Objective: Human plasma is used for the generation of several life-saving drugs and contains valuable antibodies from the immunoglobulin classes IgG, IgM and IgA. Purified intravenous IgG solutions (IVIGs) form the majority of plasma-derived medicine to treat patients with various forms of immunodeficiencies. In conventional IVIG manufacturing processes, immunoglobulin classes IgM and IgA are often discarded as contaminants, but these antibody classes have been proven to be effective for the treatment of acute bacterial infections.
View Article and Find Full Text PDFPeripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles.
World J Biol Psychiatry
November 2023
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Background: Rates of Cannabis Use Disorder (CUD) are highest amongst young adults. Paucity of brain tissue samples limits the ability to examine the molecular basis of cannabis related neuropathology. Proteomic studies of neuron-derived extracellular vesicles (NDEs) isolated from the biofluids may reveal markers of neuropathology in CUD.
View Article and Find Full Text PDFStructure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging.
Protein Sci
October 2022
Department of Molecular Biology and Genetics, Section for Protein Science, Aarhus Universitet, Aarhus, Denmark.
Article Synopsis
- Researchers developed a method to stabilize labile macromolecular complexes by using peptide tags and nanobodies to prevent dissociation during crystallization or electron microscopy preparation.
- This technique enabled them to determine the crystal structure of a large 320 kDa proconvertase complex with a high resolution of 3.9 Å.
- The study highlights the importance of specific structural features in properdin for enhancing C3 convertase activity and suggests that this nanobody bridging approach could be valuable for studying other unstable complexes in biochemistry.
Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20.
Front Immunol
April 2021
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can initiate the alternative complement pathway (AP). Properdin however, also binds to C3b(Bb) and properdin binding to tubular cells might be influenced by the presence of C3b(Bb) on tubular cells and/or by variability in properdin proteins .
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