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Comparison of clinical effects between sacrospinous ligament fixation and extraperitoneal high uterosacral ligament suspension for patients: A retrospective cohort clinical trials.
J Obstet Gynaecol Res
March 2025
Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
Aim: The aim of the study is to compare the effect of extraperitoneal high uterosacral ligament suspension (EHUS) and sacrospinous ligament fixation on lower urinary tract symptoms (LUTS) and anatomical reduction in patients with pelvic organ prolapse (POP).
Methods: This retrospective cohort study concluded 91 patients with POP who underwent EHUS or sacrospinous ligament fixation (SSLF) for apical repair. The primary outcome was the effect of the two operations on anatomical reduction.
Predictors of treatment failure with parasacral transcutaneous electrical nerve stimulation in children and adolescents with bladder and bowel dysfunction.
J Pediatr Urol
January 2025
Center for Children's Urinary Disorders (CEDIMI), Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil.
Introduction: Parasacral Transcutaneous Electrical Nerve Stimulation (parasacral TENS) has emerged as a promising treatment for children with Bladder and Bowel Dysfunction (BBD), being an efficient method without direct adverse effects. Little is known about clinical characteristics associated with poorer treatment outcomes in this specific patient group.
Objective: To evaluate potential clinical predictors of parasacral TENS treatment failure in children and adolescents with BBD.
Efficacy and safety of solifenacin for overactive bladder: An updated systematic review and meta-analysis.
Urol Ann
January 2025
Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
Overactive bladder (OAB) is a chronic disease with the symptoms of urgency with or without incontinence. Solifenacin is an antimuscarinic drug that Excels in OAB treatment due to its specific bladder receptor targeting. While previous research had positive outcomes, reports of adverse events (AEs) highlight the need for regular updates on the safety and efficacy of solifenacin for OAB management.
View Article and Find Full Text PDFi-Flow: Design and evaluation of a wearable uroflowmeter with non-invasive low power bio-impedance sensing.
Annu Int Conf IEEE Eng Med Biol Soc
July 2024
Urological problems involving lower urinary tract symptoms (LUTS) such as urinary frequency, urgency, nocturia, and urine volume have a significant impact on patient health and quality of life. At present, clinical uroflowmeter tests and a urination frequency-volume chart (FVC) or bladder diary is recommended for monitoring the symptoms and the efficacy of treatment. However, these solutions are intermittent, needing high user compliance, repeated visits to the clinic and are inconvenient, especially for elderly patients.
View Article and Find Full Text PDFStandardized Leaf Extract Exhibited Antiproliferative Activity Against TGF-β-induced Prostate Stromal Cells (WPMY-1) Through G 1 Phase Cell Cycle Arrest SMAD2/3 and ERK1/2 Signaling Pathways.
In Vivo
February 2025
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
Background/aim: Benign prostatic hyperplasia (BPH) is characterized by the abnormal proliferation of prostate stromal cells, resulting in the enlargement of the prostate gland and the manifestation of troublesome symptoms, such as nocturia, urinary retention, and urinary incontinence. Dihydrotestosterone (DHT) and interleukin-17 (IL-17) are known to be key factors in promoting the overproduction of transforming growth factor-beta (TGF-β) in prostate stromal cells, contributing to their excessive proliferation, leading to BPH.
Materials And Methods: In this study, selected plant extracts traditionally used to alleviate urinary symptoms were subjected to primary screening for their anti-proliferative activity by evaluating DHT- and IL-17-induced proliferation in WPMY-1 prostate stromal cells.
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