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Advances in sulodexide-based long-term anticoagulation for a myasthenia gravis patient with giant thymoma.
Front Pharmacol
February 2025
Department of Intensive Care Unit, Renmin Hospital of Wuhan University, Wuhan, China.
This case report describes a geriatric male patient with myasthenia gravis (MG) secondary to giant thymoma, presenting with progressive muscle weakness and ptosis. The diagnosis of MG was confirmed through pathology, imaging, and laboratory evaluations. Considering the significant surgical risks associated with the giant thymoma, adjuvant chemotherapy was initiated.
View Article and Find Full Text PDFLong-Term Safety and Effectiveness of Rituximab Biosimilar RTXM83: A Retrospective Extension Study in Brazilian Patients with Diffuse Large B-Cell Lymphoma.
Oncol Ther
September 2024
Medical Affairs, Libbs Farmacêutica, São Paulo, São Paulo, Brazil.
Article Synopsis
- RTXM83, a biosimilar to rituximab, has been approved after extensive studies showed it is similar to the original drug; this includes results from a pivotal study called RTXM83-AC-01-11.
- A retrospective study in Brazil analyzed long-term outcomes for patients with diffuse large B cell lymphoma (DLBCL) who received either RTXM83 or the original rituximab alongside other chemotherapy drugs, revealing that both groups showed significant progress in treatment.
- The findings highlighted that RTXM83 had a much higher progression-free survival and overall survival rate compared to the original drug, indicating its effectiveness and safety, although further research is needed to confirm these results in
Anti-inflammatory, antioxidant and anti-mitophagy effects of trans sodium crocetinate on experimental autoimmune encephalomyelitis in BALB/C57 mice.
Metab Brain Dis
June 2024
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Multiple sclerosis (MS) is an autoimmune disorder characterized by the degeneration of myelin and inflammation in the central nervous system. Trans sodium crocetinate (TSC), a novel synthetic carotenoid compound, possesses antioxidant, anti-inflammatory and neuroprotective effects. This study aimed to evaluate the protective effects of TSC against the development of experimental autoimmune encephalomyelitis (EAE), a well-established model for MS.
View Article and Find Full Text PDFA randomised trial of oral prednisone for cystic fibrosis pulmonary exacerbation treatment.
Eur Respir J
June 2024
Translational Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- Elevated inflammation markers in cystic fibrosis (CF) patients can hinder lung function recovery after exacerbations; the study aimed to see if oral prednisone could help patients who weren’t improving with antibiotics.
- A randomized trial with 173 CF patients tested the effectiveness of prednisone against a placebo after 7 days of antibiotic treatment, measuring recovery of lung function (FEV).
- The results showed no significant difference in lung function recovery between the prednisone group (50% recovery) and the placebo group (39%), suggesting prednisone does not provide additional benefits for these patients.*
Primary thyroid lymphoma: a case series.
J Med Case Rep
February 2024
Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Introduction: Primary Thyroid Lymphoma (PTL) is defined as lymphoma involving the thyroid gland alone or the thyroid gland and adjacent neck lymph nodes without contiguous spread or distant metastases at the time of diagnosis. Most thyroid lymphomas are B cell lymphomas, and 98% of all PTL cases are non-Hodgkin's lymphoma. It is a rare disease accounting for around 5% of the thyroid neoplasms and 2% of extranodal lymphomas.
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