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Quantitative F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis.
Arthritis Res Ther
December 2024
Department of Rheumatology and Clinical Immunology, Amsterdam UMC, Meibergdreef 9, Room G7-126, Amsterdam, 1105 AZ, the Netherlands.
Background: This study aimed to assess the quantitative uptake of F-FDG PET-CT in the lungs of patients with early severe diffuse cutaneous systemic sclerosis (SSc) with and without interstitial lung disease (ILD), compared to controls. In patients with SSc-ILD, F-FDG uptake was correlated to high-resolution computed tomography (HRCT) and pulmonary function test (PFT) parameters.
Methods: A prospective, cross-sectional study was conducted, involving 15 patients with SSc-ILD, 5 patients with SSc without ILD, and 7 controls without SSc.
Heart transplantation in juvenile-onset systemic sclerosis with primary cardiac involvement: report of two cases and comprehensive literature review.
Curr Probl Cardiol
January 2025
Cardiac Surgery Unit, Department of Cardio-Thoracic-Vascular Sciences and Public Health, Padova University Hospital, via Giustiniani 2, 35128, Padova, Italy. Electronic address:
Juvenile onset systemic sclerosis is a rare chronic multisystem connective tissue disease characterized by skin induration, microangiopathy, autoimmune disturbances and widespread fibrosis of internal organs. Primary cardiac involvement in systemic sclerosis (SSc) is associated with a variable phenotype, including heart failure and arrhythmias, which lead to poor short-term prognosis. Isolated heart transplantation is a rare approach for the treatment of advanced heart failure in patients with systemic sclerosis.
View Article and Find Full Text PDFImaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosis.
Ann Rheum Dis
October 2024
Department of Rheumatology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Nordrhein-Westfalen, Germany
Article Synopsis
- * Researchers identified 13 distinct fibroblast subpopulations, noting an increase in five subpopulations linked to more severe skin fibrosis and a decrease in three associated with milder fibrosis.
- * The findings suggest that certain fibroblast subpopulations, such as S1PR and PI16;FAP-fibroblasts, could serve as potential targets for treatment and may help in assessing the severity of skin fibrosis in patients with SSc.
Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology.
Int J Mol Sci
September 2024
Heersink School of Medicine, University of Alabama-Birmingham, Birmingham, AL 35233, USA.
Article Synopsis
- Many skin diseases start with inflammation at a molecular level, so understanding these mechanisms is crucial for better treatment options.
- The research highlights various stages of the inflammatory response, including issues with immunity and interactions between immune and nerve systems.
- The review focuses on recent studies from 2019 to 2024 that explore inflammatory processes in skin diseases like psoriasis and atopic dermatitis, emphasizing their potential for therapeutic breakthroughs.
Quantitative chest computed tomography predicts mortality in systemic sclerosis: A longitudinal study.
PLoS One
September 2024
Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Objective: Quantitative chest computed tomography (qCT) methods are new tools that objectively measure parenchymal abnormalities and vascular features on CT images in patients with interstitial lung disease (ILD). We aimed to investigate whether the qCT measures are predictors of 5-year mortality in patients with systemic sclerosis (SSc).
Methods: Patients diagnosed with SSc were retrospectively selected from 2011 to 2022.
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