Enteric coated naproxen (Nycopren) was compared with standard naproxen in a double blind comparative trial of 348 patients with either rheumatoid or osteoarthritis. There were slightly fewer gastric side effects and slightly fewer withdrawals because of side effects in the enteric coated naproxen group but the differences did not reach statistical significance. There was no significant difference in the efficacy of the two formulations. A satisfaction index was used to assess the therapeutic ratio with visual analogue scales assigned to both efficacy and side effects. The scale performed as intended and is worthy of further exploration.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Effects of probiotic therapy combined with personalized nursing on immune function and nursing compliance in children with acute gastroenteritis.
Afr J Reprod Health
November 2024
Department of Neonatology, The First Hospital of China Medical University, Shenyang, 110002, Liaoning, China.
This was an original study that mainly explored the effect of probiotic therapy and personalized nursing on immune function in children with acute gastroenteritis. One hundred and twelve (112) children with acute gastroenteritis were selected and divided into an intervention group and a control group. The control group accepted omeprazole enteric-coated capsules and routine nursing.
View Article and Find Full Text PDFBerberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis.
Int J Biol Macromol
January 2025
Pharmacy School, Jinzhou Medical University, Jinzhou, China; Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, China; Key Laboratory of Medical Tissue Engineering of Liaoning Province, Jinzhou Medical University, Jinzhou, China. Electronic address:
In this study, we developed calcium alginate-coated nanovesicles derived from macrophage membranes loaded with berberine (Ber@MVs-CA) for the oral treatment of ulcerative colitis (UC). Ber@MVs-CA demonstrates resistance to gastric acid and controlled drug release in the colonic pH environment, while actively targeting sites of ulcerative colitis injury. pH-responsive release of Ber in Ber@MVs-CA was confirmed through in vitro release experiments.
View Article and Find Full Text PDFIn Vivo Animal Spices and Experimental Technique to Evaluate Sustained Release Granules.
Biopharm Drug Dispos
January 2025
Bioavailability Research Project, Formulation Research Institute, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan.
Establishment of a suitable animal model to evaluate sustained release (SR) formulations is very important because it reduces the development time of SR formulations. Beagle dogs are often used to evaluate prototype formulations since they can be directly administered powder, such as drug substance. However, the physiological condition of dogs is very different to that of humans.
View Article and Find Full Text PDFPreliminary establishment and evaluation of a rapid detection method for GII human norovirus based on time-resolved fluorescence chromatography.
Anal Methods
January 2025
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People's Republic of China.
Article Synopsis
- Human norovirus leads globally in causing stomach infections across all ages.
- A new detection method using time-resolved fluorescence microsphere immunochromatography was developed, maximizing sensitivity and speed for identifying the VP1 protein of norovirus GII in only 15 minutes.
- The method displays high accuracy with a 96.60% overall coincidence rate in clinical samples, indicating its potential for quick and effective diagnostics in healthcare settings.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!