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Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin-Driven TFEB Nuclear Translocation.
Clin Exp Pharmacol Physiol
March 2025
School of Physical Education, Hangzhou Normal University, Hangzhou, China.
Exercise activates autophagy and lysosome system in skeletal muscle, which are known to play an important role in metabolic adaptation. However, the mechanism of exercise-activated autophagy and lysosome system in obese insulin resistance remains covert. In this study, we investigated the role of exercise-induced activation of autophagy and lysosome system in improving glucose metabolism of skeletal muscle.
View Article and Find Full Text PDFLoading Speed and Intensity in Eccentric Calf Training Impact Acute Changes in Achilles Tendon Thickness and Stiffness: A Randomized Crossover Trial.
Med Sci Sports Exerc
December 2024
Department of Rehabilitation Sciences, Ghent University, Ghent, BELGIUM.
Purpose: Eccentric calf training for Achilles tendinopathy shows variable success in athletes. Recent insights suggest a role for tendon fluid flow (exudation or redistribution) during exercise, which explains post-exercise reductions in thickness and increases in stiffness of the tendon. This fluid flow is thought to be beneficial as it may promote tendon remodeling, reduce intratendinous pressure, and alleviate pain.
View Article and Find Full Text PDFSleep Deprivation Elevates Resting and Exercise Blood Pressures and Augments Pressor Response at Exercise Onset.
Med Sci Sports Exerc
December 2024
College of Life and Health Sciences, Chubu University, Kasugai, Aichi, JAPAN.
Purpose: Sleep deprivation and elevated blood pressure (BP) increase the risk of cardiovascular diseases. However, the effects of sleep deprivation on BP response, especially at exercise onset remain unclear. We aimed to elucidate the effects of experimental sleep deprivation (ESD) on resting and exercise BPs, including that at exercise onset, and investigate whether a night-time nap during ESD changes the ESD-altered BP.
View Article and Find Full Text PDFAlternating Aerobics with Resistance Exercise Improves Bone Density and Circulating Irisin Levels in Postmenopausal Women.
Med Sci Sports Exerc
December 2024
Shanghai University of Sport, Shanghai, CHINA.
Purpose: Irisin plays an important role in bone-muscle crosstalk. The aim of this study was to elucidate the association of long-term exercise induced irisin response with body composition and bone mineral density in postmenopausal women.
Methods: We recruited 29 postmenopausal women (age: 62.
Acute Effect of High-Intensity Interval Exercise on Blood Pressure in Females Living with Type 2 Diabetes and Hypertension.
Med Sci Sports Exerc
December 2024
School of Health and Exercise Sciences, University of British Columbia-Okanagan Campus, Kelowna, BC, CANADA.
Background: The acute effects of high-intensity interval training (HIIT) on blood pressure (BP) may depend on the exercise protocol performed. Purpose: To compare the acute effect of high and low-volume HIIT on post-exercise and ambulatory BP in untrained older females diagnosed with both type 2 diabetes (T2D) and hypertension (HTN). Methods: Fifteen females (69 [65 ─ 74] years) completed a crossover study with three experimental conditions: 1) REST (35 min in sitting position); 2) HIIT10 (10 × 1 min at 90% heart rate max [HRmax]), and 3) HIIT4 (4 × 4 min at 90% HRmax).
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