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Biomarkers.
Alzheimers Dement
December 2024
University of Kansas Medical Center, Kansas City, KS, USA.
Background: States of altered metabolic health such as metabolic syndrome (MetS), obesity, and insulin resistance increase Alzheimer's Disease (AD) risk. Individuals with these conditions, like those with AD, have demonstrated changes in the structural and functional features of the Default Mode Network (DMN). Here, we characterize associations between systemic metabolic dysfunction, brain structure (Cortical Thickness and Hippocampal Volume) and functional connectivity of DMN subnetworks.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.
Background: States of altered metabolic health such as metabolic syndrome (MetS), obesity, and insulin resistance increase Alzheimer's Disease (AD) risk. Individuals with these conditions, like those with AD, have demonstrated changes in the structural and functional features of the Default Mode Network (DMN). Here, we characterize associations between systemic metabolic dysfunction, brain structure (Cortical Thickness and Hippocampal Volume) and functional connectivity of DMN subnetworks.
View Article and Find Full Text PDFSingle-port Laparoscopic Bilateral Orchiectomy via Total Extraperitoneal Approach in Androgen Insensitivity Syndrome.
J Minim Invasive Gynecol
January 2025
Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea. Electronic address:
New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx.
Sci Rep
December 2024
Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
This study examined the incidence, characteristics, and risk factors of new gastrointestinal disorders (GID) associated with SARS-CoV-2 infection up to 3.5 years post-infection. This retrospective study included 35,102 COVID-19 patients and 682,594 contemporary non-COVID-19 patients without past medical history of GID (controls) from the Montefiore Health System in the Bronx (3/1/2020 to 7/31/2023).
View Article and Find Full Text PDFExpanding the Molecular Landscape of Androgen Insensitivity Syndrome Through Next-Generation Sequencing.
Appl Clin Genet
December 2024
Department of Genetics, Polish Mother's Memorial Hospital Research Institute, Lodz, 93-338, Poland.
Androgen insensitivity syndrome (AIS) is an X-linked genetic disorder caused by mutations in the androgen receptor gene (), leading to impaired androgen signaling and resulting in varying degrees of undermasculinization in individuals with a 46,XY karyotype. This study aimed to expand the molecular landscape of AIS by identifying and characterizing pathogenic variants in the gene via next-generation sequencing (NGS). Molecular diagnostics revealed eight distinct variants within the gene, two of which had not been previously described.
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