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Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway.
BMC Nephrol
January 2025
Department of Intensive Care Medicine, No. 971st Hospital of the People's Liberation Army Navy, Qingdao, Shandong Province, PR China.
Background: Ursodeoxycholic acid (UDCA), traditionally recognized for its hepatoprotective effects, has also shown potential in protecting kidney injury. This study aimed to evaluate the protective effects of UDCA against sepsis-induced acute kidney injury (AKI) and to elucidate the underlying mechanisms.
Methods: Sixty male C57BL/6 N mice were utilized to establish a sepsis-induced AKI model through intravenous injection of lipopolysaccharides (LPS, 10 mg/kg).
A two-stage model of the fuzzy analytic hierarchy process and the fuzzy synthetic evaluation technique to prioritize sustainable sanitation services under uncertainty.
Sci Rep
January 2025
Department of Civil Engineering & Sustainable Structures, Technical University (Kadoorie), Jaffa Street, P.O. Box (7), Tulkarem, Palestine.
In the context of the Sustainable Development Goals (SDGs), which strive to ensure comprehensive access to fundamental water, sanitation, and hygiene (WASH) services, it is extremely imperative to prioritize communities in need and still disadvantaged. Moreover, tackling the worldwide sanitation crisis entails advancing the development of productive and sustainable sanitation systems and infrastructure. Sanitation planning is a multidimensional exercise encompassing multiple dimensions, stakeholders, and strategies, typically with conflicting objectives.
View Article and Find Full Text PDFAtopic dermatitis (AD) is a prevalent condition that has been associated with stress, but epidemiologic data on the impact of both common and severe childhood stressors are limited. Our objective was to evaluate the impact of stressful life events throughout early childhood on AD activity and severity. We conducted a longitudinal cohort study of 13,972 children ages 1 to 8.
View Article and Find Full Text PDFThe impact of infertility on the mental health of women undergoing in vitro fertilization treatment.
Sex Reprod Healthc
January 2025
Department of Obstetrics & Gynecology, Patras University School of Medicine, Greece. Electronic address:
Background & Problem: Infertility affects a substantial number of couples, posing physical, emotional, and psychological challenges. Infertile women experienced a sense of loss of control and planning of life with high stress and anxiety and they must deal with the uncertainty of treatment. The evolution of assisted reproductive techniques has provided hope for couples that struggle with infertility.
View Article and Find Full Text PDFLinking citation and retraction data reveals the demographics of scientific retractions among highly cited authors.
PLoS Biol
January 2025
Research Intelligence, Elsevier B.V., Amsterdam, the Netherlands.
Retractions are becoming increasingly common but still account for a small minority of published papers. It would be useful to generate databases where the presence of retractions can be linked to impact metrics of each scientist. We have thus incorporated retraction data in an updated Scopus-based database of highly cited scientists (top 2% in each scientific subfield according to a composite citation indicator).
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