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Role of Exercise Stress Echocardiography in Systemic Sclerosis: Pathophysiological and Prognostic Significance of the Systemic Sclerosis with a Heart Failure and Preserved Ejection Fraction Phenotype.
Eur Heart J Cardiovasc Imaging
January 2025
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Aims: Left ventricular (LV) diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) are common cardiac complications of patients with systemic sclerosis (SSc). Exercise stress echocardiography is often used in symptomatic patients with SSc to detect abnormal increases in pulmonary pressures during exercise, but the pathophysiologic and prognostic significance of exercise stress echocardiography to assess the presence of HFpEF in these patients is unclear.
Methods And Results: Patients with SSc (n=140) underwent ergometry exercise stress echocardiography with simultaneous expired gas analysis.
Faster intervals, faster recoveries - intensified short VO running intervals are inferior to traditional long intervals in terms of time spent above 90% VO.
Front Sports Act Living
January 2025
Department of Endurance Sports, Institute for Applied Training Science, Leipzig, Germany.
Introduction: High intensity interval training for improving maximal oxygen consumption (VO) is a fundamental component of specific preparation phases for middle- and long-distance runners. In this context, short intervals are very popular in practice. The aim of the present study was to determine whether increasing the intensity of short intervals around maximal aerobic speed (vVO), compared to traditional long interval runs, leads to a greater time spent above 90% VO.
View Article and Find Full Text PDFDengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.
iScience
January 2025
Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Québec H7V 1B7, Canada.
During infection, dengue virus (DENV) and Zika virus (ZIKV), two (ortho)flaviviruses of public health concern worldwide, induce alterations of mitochondria morphology to favor viral replication, suggesting a viral co-opting of mitochondria functions. Here, we performed an extensive transmission electron microscopy-based quantitative analysis to demonstrate that both DENV and ZIKV alter endoplasmic reticulum-mitochondria contact sites (ERMC). This correlated at the molecular level with an impairment of ERMC tethering protein complexes located at the surface of both organelles.
View Article and Find Full Text PDFUnderstanding the limitations of substrate degradation in bioelectrochemical systems.
Front Microbiol
January 2025
School of Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.
Microbial Fuel Cells (MFCs) are innovative environmental engineering systems that harness the metabolic activities of microbial communities to convert chemical energy in waste into electrical energy. However, MFC performance optimization remains challenging due to limited understanding of microbial metabolic mechanisms, particularly with complex substrates under realistic environmental conditions. This study investigated the effects of substrate complexity (acetate vs.
View Article and Find Full Text PDFmTOR signaling mediates energy metabolic equilibrium in bovine and mouse oocytes during the ovulatory phase†.
Biol Reprod
January 2025
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, National Center for International Research on Animal Genetics, Breeding and Reproduction, College of Animal Sciences and Technology/Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
The mammalian target of rapamycin (mTOR) signaling pathway is activated by luteinizing hormone in preovulatory follicle. However, its impact on ovulation remains inadequately explored. Utilizing in vivo studies and in vitro fertilization, we demonstrated that the negative effect of inhibition of mTOR signaling by rapamycin on oocyte quality during the ovulatory phase, with a notable decrease in the total cell count of blastocysts, a reduction in gastrula size, and fetal degeneration on the 16th day of gestation while not affecting ovulated oocyte count or granulosa cell luteinization.
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