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Multiple metastasis of malignant melanoma. The diagnostic role of ultrasonography starting from a parotid tumor.
Med Ultrason
March 2024
Department of Gastroenterology, "Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca.
We presented the case of a patient with a slowly developing right parotid tumor over the course of several years. Multimodal ultrasonography proved relevant for malignancy. Subsequent imaging identified tumors in numerous organs, considered metastases.
View Article and Find Full Text PDFDual action of leptin on rest-firing and stimulated catecholamine release via phosphoinositide 3-kinase-driven BK channel up-regulation in mouse chromaffin cells.
J Physiol
November 2015
Department of Drug Science and Technology, University of Torino, Torino, Italy.
Article Synopsis
- Leptin, an adipokine from adipose tissue, regulates body weight and appetite, and influences adrenal chromaffin cells' function.
- At rest, leptin reduces action potential firing in these cells by enhancing BK channel activity; however, this effect is lost in mice lacking Ob receptors.
- During sustained stimulation, leptin maintains excitability and increases catecholamine release, showing its crucial role in the adipo-adrenal axis and sympathetic nervous system activity.
[Diagnosis of an initial infratentorial central nervous system B-cell lymphoma during prolonged cortisone medication].
Nervenarzt
December 2004
Abteilung für Neurologie, Klinikum der RWTH Aachen.
We present a patient with primary central nervous system B-cell lymphoma. He had suffered from slowly developing weight loss and presented to us with disorientation, seizures, and a supranuclear gaze disturbance. The patient was dismissed with the primary diagnosis of autoimmune encephalitis of the brainstem and put on oral corticosteroids.
View Article and Find Full Text PDFRegulation of cell surface expression of voltage-dependent Nav1.7 sodium channels: mRNA stability and posttranscriptional control in adrenal chromaffin cells.
Front Biosci
May 2004
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889-1692, Japan.
Regulated expression of Na+ channels is indispensable to physiological events, whereas dysregulated expression of otherwise silent or even normal Na+ channel isoforms causes Na+ channelopathies; however, the regulatory mechanisms remain unknown. In quiescent cultured bovine adrenal chromaffin cells, constitutive phosphorylation/activation of extracellular signal-regulated kinase-1 (ERK1) and ERK2 destabilized Nav l.7 Na+ channel alpha-subunit mRNA and decreased its level without altering alpha-subunit gene transcription, thus negatively regulating steady-state level of Na+ channels.
View Article and Find Full Text PDFActivation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels.
Endocrinology
May 2002
European Institute for Peptide Research (IFRMP 23), Institut National de la Santé et Recherche Médicale Unité-413, Unité Affiliée Centre National de la Recherche Scientifique, University of Rouen, 76821 Mont-Saint-Aignan, France.
Serotonin (5-HT) stimulates aldosterone secretion from the rat adrenal gland through 5-HT(7) receptors. The aim of the present study was to investigate the transduction mechanisms associated with activation of 5-HT(7) receptors in rat glomerulosa cells. The stimulatory effect of 5-HT on aldosterone secretion and cAMP formation was significantly reduced by the 5-HT(7) receptor antagonist LY 215840.
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