Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Fructose-Induced Alteration of the Heart and Vessels Homeostasis.
Curr Probl Cardiol
February 2023
Yerevan State Medical University after M.Heratsi, Armenia; L. A. Orbeli Institute of Human Physiology, Armenia. Electronic address:
To date, the role of uncontrolled sugar consumption in the triggering and progression of cardiovascular events is undeniable. Modern concepts offer a new hypothesis regarding the direct myocardiotoxic effects of fructose. Experimental studies have demonstrated that cardiomyocytes have a unique ability to transport and use fructose along with the expression of all components involved in fructose metabolism.
View Article and Find Full Text PDFOxidative stress-mediated myocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats.
Drug Chem Toxicol
October 2009
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Eskişehir, Turkey.
In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malondialdehyde and nitric oxide levels were measured.
View Article and Find Full Text PDFMetallothionein acts as a cytoprotectant against doxorubicin toxicity.
J Pharmacol Exp Ther
January 2000
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
The protective role of metallothionein (MT) against the myocardiotoxicity and hepatotoxicity of doxorubicin (Dox) was investigated in mice. Dox-induced elevations of plasma creatine kinase activity, a measure of myocardiac damage, and plasma glutamate pyruvate transaminase activity, reflecting hepatic damage, were prevented by pretreatment with an MT inducer. Pretreatment with zinc induced MT in the liver and heart, thereby reducing Dox toxicity in these two organs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!