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Metagenome-assembled genomes from irradiated human dental plaque.
Microbiol Resour Announc
December 2024
CIBIO, University of Trento, Trento, Italy.
We provide 309 quality-controlled bacterial metagenome-assembled genomes recovered from supragingival plaque metagenomes. Samples were collected from head and neck cancer patients following radiotherapy, so the recovered genomes can be useful to investigate the effects of oral cavity irradiation on oral microbiome members.
View Article and Find Full Text PDFResolution of selective fetal growth restriction after laser surgery for twin-to-twin transfusion syndrome can be predicted by predisease growth discordance.
Ultrasound Obstet Gynecol
January 2025
Johns Hopkins Center for Fetal Therapy, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Objective: To determine if the resolution of fetal growth discordance after laser surgery in pregnancies with twin-to-twin transfusion syndrome (TTTS) and coexisting selective fetal growth restriction (sFGR) can be predicted by estimated fetal weight (EFW) discordance recorded prior to the development of TTTS (pre-TTTS).
Methods: This was a single-center, retrospective analysis of prospectively collected data on monochorionic twins with concurrent TTTS and sFGR that underwent laser surgery and had available growth ultrasound records from a pre-TTTS ultrasound evaluation. Maternal demographics, pregnancy characteristics and birth outcomes were compared between three outcome groups: double twin survival with resolved sFGR determined by birth weight discordance (BWD) < 20%; double twin survival with ongoing sFGR determined by BWD ≥ 20%; and single or double fetal demise after laser surgery.
Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function.
BMC Genomics
December 2024
Department of Epidemiology and Health Statistics, The College of Public Health, Qingdao University, NO. 308 Ning Xia Street, Qingdao, Shandong Province, 266071, People's Republic of China.
Background: Previous genome-wide association studies (GWAS) have established association between genetic variants and pulmonary function across various ethnics, whereas such associations are scarcely reported in Chinese adults. Therefore, we conducted an GWAS to explore relationships between genetic variants and pulmonary function among middle-aged Chinese dizygotic twins and further validated the top variants using data from the UK Biobank (UKB).
Methods: In the discovery phase, 139 dizygotic twin pairs were drawn from the Qingdao Twin Registry.
Suboptimal dietary patterns are associated with accelerated biological aging in young adulthood: A study with twins.
Clin Nutr
December 2024
Faculty of Sport and Health Sciences, Gerontology Research Center, University of Jyväskylä, 40014 Jyväskylä, Finland; The Wellbeing Services County of Central Finland, 40620 Jyväskylä, Finland. Electronic address:
Background & Aims: Suboptimal diets increase morbidity and mortality risk. Epigenetic clocks are algorithms that can assess health and lifespan, even at a young age, before clinical manifestations of diseases. We investigated the association between dietary patterns and biological aging in young adult twins.
View Article and Find Full Text PDFConcurrent stress modulates the acute and post-acute effects of psilocybin in a sex-dependent manner.
Neuropharmacology
December 2024
Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Edifício Egas Moniz, 1649-028, Lisboa, Portugal; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Edifício Egas Moniz, 1649-028, Lisboa, Portugal; Gulbenkian Institute for Molecular Medicine, Avenida Professor Egas Moniz, 1649-035 Lisboa, Portugal. Electronic address:
Article Synopsis
- There is growing interest in using psychedelics like psilocybin to treat hard-to-manage psychiatric disorders, but little is known about how the experiences they create affect mood afterward.
- In experiments with mice, it was found that psilocybin increased head-twitch responses more in females than in males, highlighting a sex difference in its effects.
- Stress exposure during or after taking psilocybin impacted anxiety-like behavior in males, blocking its calming effects, while females only experienced a partial effect, suggesting that both sex and the context of the experience are important in understanding the drug's impact.
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