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Cocatalysis of catalytic hairpin assembly and ternary heterojunction BiS@MoS@BiMoO promotes ultra-sensitive electrochemical of detection MiRNA-21.
Mikrochim Acta
January 2025
USST-UH International Joint Laboratory for Tumor Diagnosis and Energy Treatment, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Ternary heterojunction BiS/MoS/BiMoO was designed as a signal probe to develop a dual signal amplification strategy empowered electrochemical biosensor for sensitive miRNA-21 detection by combining with catalytic hairpin assembly (CHA). The combination of the BiS/MoS/BiMoO heterojunction as a tracer indication probe and the CHA amplification strategy not only took fully use of the highly dense nanowire interwoven structure and superior active region of the probe, but also endowed the ability to improve the molecular hybridization efficiency by collision, which significantly avoided the cumbersome chain design and greatly simplified the step-by-step construction of the electrode surface. Hairpin H1 was first added dropwise to the gold nanoparticle-decorated electrode surface, and then opened by the introduced miRNA-21 to initiate the specific hybridization.
View Article and Find Full Text PDFOptimizing Skin Cancer Diagnosis: A Modified Ensemble Convolutional Neural Network for Classification.
Microsc Res Tech
January 2025
Department of Computing Technologies, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India.
Skin cancer is recognized as one of the most harmful cancers worldwide. Early detection of this cancer is an effective measure for treating the disease efficiently. Traditional skin cancer detection methods face scalability challenges and overfitting issues.
View Article and Find Full Text PDFEvaluation of Effects of Verbal and Video-Based Instructions on the Improvement of Oral Hygiene Status in Children: A Randomised Clinical Trial.
Int J Dent Hyg
January 2025
Periodontology Department, Faculty of Dentistry, Ankara University, Ankara, Turkey.
Objectives: To evaluate the effects of verbal and video-based oral hygiene instructions (OHIs) on the improvement of the oral hygiene status (OHS) in children of different age groups in the mixed dentition period.
Methods: In total, 202 children aged 6-9 and 10-12 years (n = 101 each) were included. Before providing the OHIs, the baseline OHS was determined using the Simplified Oral Hygiene Index (OHI-S).
The Nano Exposure Quantifier: a quantitative model for assessing nanoparticle exposure in the workplace.
Ann Work Expo Health
January 2025
TNO, Princetonlaan 6, PO Box 80015, Utrecht 3584 CB, The Netherlands.
Exposure to manufactured nanomaterials (MNs) is a growing concern for occupational health and safety. Reliable methods for assessing and predicting MN exposure are essential to mitigate associated risks. This study presents the development of the Nano Exposure Quantifier (NEQ), a mechanistic model designed to assess airborne MN exposure in the workplace.
View Article and Find Full Text PDFDetection of Oral Fluid Stains on Fabric via Solution Extraction Combined with Deep Ultraviolet Raman Spectroscopy.
Anal Chem
January 2025
Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, United States.
DNA phenotyping plays a central role in modern practical forensics, yet an overwhelming amount of evidence creates significant backlogs in all major crime laboratories. A fast nondestructive test of a potential biological stain prior to DNA phenotyping should reduce the number of irrelevant samples for the analysis and increase the efficiency of the overall process. Evidence items recovered from the crime scene can often include body fluid traces, such as oral fluid (OF).
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