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The Masquerading Myocarditis: A Case of Late Recurrence of Acute Myocarditis Presenting as "Peripartum Cardiomyopathy".
Cureus
April 2024
Heart Failure and Transplantation Cardiology, Piedmont Heart Institute Athens, Athens, USA.
Myocarditis is a potentially fatal medical condition with varied etiologies. Peripartum cardiomyopathy (PPCM) refers to systolic dysfunction occurring toward the end of pregnancy or in the months following delivery; it is a diagnosis of exclusion. We present a patient with chest pain, bipedal edema, markedly elevated troponins, electrocardiogram (EKG) findings that were concerning for myocardial infarction, and a significantly reduced left ventricular ejection fraction (LVEF) on the echocardiogram.
View Article and Find Full Text PDFStorytelling of Myocarditis.
Biomedicines
April 2024
Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35121 Padua, Italy.
In 1900, Fiedler first reported autopsy cases with peculiar inflammation of the myocardium, which he named interstitial myocarditis. He postulated an isolated cardiac inflammation of the myocardium in the absence of multiorgan involvement and with a poor prognosis due to invisible microorganisms, which years later would have been identified as viruses. The revision of original histologic sections by Schmorl showed cases with lymphocytes and others with giant-cell inflammatory histotypes.
View Article and Find Full Text PDF[Lethal lymphocytic myocarditis-an underestimated diagnosis in infancy and childhood?].
Pathologie (Heidelb)
December 2023
Universitätsklinikum Gießen & Marburg, Justus-Liebig-Universität Gießen, Frankfurter Str. 58, 35392, Gießen, Deutschland.
In the past, histological diagnosis of (post-)viral myocarditis was based on the so-called Dallas criteria, which have been criticized because of high interobserver variability and sampling error. Immunohistochemical qualification and quantification of interstitial intramyocardial leucocytes was established and standard values concerning adults were published. Fatal casualties due to a viral myocarditis are rare as far as babies and children are concerned (sudden unexpected death in infancy; SUDI).
View Article and Find Full Text PDFExperimental infection of foot and mouth disease virus (FMDV) upregulates the expression of Coxsackie and adenovirus receptor (CAR) in the myocardium of suckling mice.
Microb Pathog
November 2023
ICAR - Indian Veterinary Research Institute, Regional campus, Hebbal, Bengaluru, Karnataka, India. Electronic address:
The relative overexpression of Coxsackie and adenoviral receptor (CAR) predisposes children to viral myocarditis. As the foot and mouth disease virus (FMDV) causes fatal myocarditis in calves, lambs, and piglets and belongs to the same family as the Coxsackie virus, we investigated the role of CAR in FMDV induced myocarditis in the suckling mice model. Swiss albino suckling mice of 5 days (n = 24) were divided into two equal groups.
View Article and Find Full Text PDFFatal Enterovirus-related Myocarditis in a Patient with Devic's Syndrome Treated with Rituximab.
Card Fail Rev
March 2021
Department of Internal Medicine and Clinical immunology, Centre de Référence des Maladies Autoimmunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), CHU Lille Lille, France.
Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses - in particular, the Coxsackie B viruses - are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody.
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