In these studies we have attempted to show that cell surface structures are critical antigens for protection against P. gingivalis-induced periodontal destruction. Fimbrillin, and in particular a synthetic 20-amino-acid fimbrillin peptide, exerts a protective effect in gnotobiotic rats, thus identifying them as potentially useful in the development of a vaccine.
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Article Synopsis
- The text discusses the significance of the Mfa1 fimbriae protein in a gram-negative anaerobe that causes periodontitis and highlights its potential as a therapeutic target.
- The study developed monoclonal antibodies (mAbs) against Mfa1 which showed effectiveness in reducing bacterial infection and inflammation in experimental models of periodontitis.
- Results indicate that anti-Mfa1 mAbs could serve as valuable tools for both diagnosing and treating Mfa1-related infections and diseases, paving the way for improved therapeutic strategies.
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