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Lurasidone versus typical antipsychotics for schizophrenia.
Cochrane Database Syst Rev
January 2025
Section of Affective Disorders, Department of Psychiatry, Jagiellonian University Medical College, Krakow, Poland.
Background: Antipsychotic drugs are the mainstay of treatment for schizophrenia. Even though several novel second-generation antipsychotics (i.e.
View Article and Find Full Text PDFIdentification of serum metabolic traits of AIWG in first-episode schizophrenia patients.
BMC Psychiatry
December 2024
Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Antipsychotic-induced weight gain (AIWG) is a common side effect of antipsychotic drugs and may lead to cardiometabolic comorbidities. There is an urgent public health need to identify patients at high risk of AIWG and determine potential biomarkers for AIWG.
Methods: In the Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments (SMART-CAT) trail, first-episode schizophrenia patients were randomly assigned to olanzapine, risperidone, perphenazine, amisulpride or aripiprazole for 8 weeks.
Amitriptyline-perphenazine therapy for persistent idiopathic facial pain: translational perspectives from a retrospective study.
J Anesth Analg Crit Care
December 2024
Pain Medicine Unit, Department of Mini-Invasive Surgery, IRCCS Maugeri, Pavia, Italy.
Background: Persistent idiopathic facial pain (PIFP) can be challenging, both in its diagnosis, which appears to be purely exclusionary, and in its treatment, which currently lacks a gold standard. Amitriptyline is considered a first-line therapy, although not always effective. Recent insights into the role of dopamine in facial pain suggest that a novel therapeutic approach could target the dopamine system.
View Article and Find Full Text PDFEffect of prophylactic perphenazine on delirium after extubation in severe acute pancreatitis.
Eur J Med Res
November 2024
Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Article Synopsis
- Severe acute pancreatitis (SAP) can lead to delirium after invasive mechanical ventilation (IMV), impacting patient recovery negatively.
- A study of 40 SAP patients found that prophylactic use of perphenazine reduced delirium incidence from 22.5%, highlighting its potential benefit.
- Fentanyl use was identified as a risk factor for delirium, and patients with delirium experienced longer hospital stays compared to non-delirium patients.
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