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A high lipid diet leads to greater pathology and lower tolerance during infection.
J Exp Biol
January 2025
Dept of Biological Sciences, University of Arkansas, Fayetteville AR 72701, USA.
Altered food landscapes contribute importantly to wildlife disease dynamics and may play an important role in host heterogeneity in disease outcomes through changes in host diet composition. We explored the effects of dietary macronutrient composition on disease pathology and feeding behavior of canaries (Serinus canaria domestica) infected with Mycoplasma gallisepticum (MG). In the first experiment, we provided canaries with isocaloric diets comprised of identical ingredients that varied in macronutrient content (high-protein or high-lipid) then MG- or sham-inoculated birds.
View Article and Find Full Text PDFThe oleaginous yeast is recognized for its remarkable lipid accumulation under nitrogen-limited conditions. However, precise control of microbial lipid production in remains challenging due to the complexity of nutrient media. We developed a two-stage fed-batch fermentation process using a well-defined synthetic medium in a 5-L bioreactor.
View Article and Find Full Text PDFLipid Metabolic Heterogeneity during Early Embryogenesis Revealed by Hyper-3D Stimulated Raman Imaging.
Chem Biomed Imaging
January 2025
College of Biomedical Engineering & Instrument Science, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310058, China.
Studying embryogenesis is fundamental to understanding developmental biology and reproductive medicine. Its process requires precise spatiotemporal regulations in which lipid metabolism plays a crucial role. However, the spatial dynamics of lipid species at the subcellular level remains obscure due to technical limitations.
View Article and Find Full Text PDFAlteration of Lipid Metabolism in Hypoxic Cancer Cells.
Chem Biomed Imaging
January 2025
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
Due to uncontrolled cell proliferation and disrupted vascularization, many cancer cells in solid tumors have limited oxygen supply. The hypoxic microenvironments of tumors lead to metabolic reprogramming of cancer cells, contributing to therapy resistance and metastasis. To identify better targets for the effective removal of hypoxia-adaptive cancer cells, it is crucial to understand how cancer cells alter their metabolism in hypoxic conditions.
View Article and Find Full Text PDFA New Strain of Preponderant Amphitriploid Clone Juvenile With Integrated Genomes Partly From White Crucian Carp () Requires Low Dietary Protein.
Aquac Nutr
January 2025
State Key Laboratory of Fresh Water Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
This study was carried out to search for the protein requirement of a new strain of preponderant amphitriploid clone, which integrated genomes partly from white crucian carp (). Seven groups of fish (body weight: 9.73 ± 0.
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